Organoid Cultures In Silico: Tools or Toys?
The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of this culture system to support their theoretical appr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/1/50 |
| _version_ | 1797445977212190720 |
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| author | Torsten Thalheim Gabriela Aust Joerg Galle |
| author_facet | Torsten Thalheim Gabriela Aust Joerg Galle |
| author_sort | Torsten Thalheim |
| collection | DOAJ |
| description | The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of this culture system to support their theoretical approaches to study tissues in silico. These groups developed computational organoid models (COMs) that enabled testing consistency between cell biological data and developing theories of tissue self-organization. The models supported a mechanistic understanding of organoid growth and maturation and helped linking cell mechanics and tissue shape in general. What comes next? Can we use COMs as tools to complement the equipment of our biological and medical research? While these models already support experimental design, can they also quantitatively predict tissue behavior? Here, we review the current state of the art of COMs and discuss perspectives for their application. |
| first_indexed | 2024-03-09T13:33:54Z |
| format | Article |
| id | doaj.art-d67d2df470ad4488b37f91cfaaed4f96 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T13:33:54Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-d67d2df470ad4488b37f91cfaaed4f962023-11-30T21:14:45ZengMDPI AGBioengineering2306-53542022-12-011015010.3390/bioengineering10010050Organoid Cultures In Silico: Tools or Toys?Torsten Thalheim0Gabriela Aust1Joerg Galle2Interdisciplinary Institute for Bioinformatics (IZBI), Leipzig University, Härtelstr. 16–18, 04107 Leipzig, GermanyDepartment of Surgery, Research Laboratories, Leipzig University, Liebigstraße 20, 04103 Leipzig, GermanyInterdisciplinary Institute for Bioinformatics (IZBI), Leipzig University, Härtelstr. 16–18, 04107 Leipzig, GermanyThe implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of this culture system to support their theoretical approaches to study tissues in silico. These groups developed computational organoid models (COMs) that enabled testing consistency between cell biological data and developing theories of tissue self-organization. The models supported a mechanistic understanding of organoid growth and maturation and helped linking cell mechanics and tissue shape in general. What comes next? Can we use COMs as tools to complement the equipment of our biological and medical research? While these models already support experimental design, can they also quantitatively predict tissue behavior? Here, we review the current state of the art of COMs and discuss perspectives for their application.https://www.mdpi.com/2306-5354/10/1/50organoidscomputational multiscale modelsstem cell organizationdisease modellingdrug response |
| spellingShingle | Torsten Thalheim Gabriela Aust Joerg Galle Organoid Cultures In Silico: Tools or Toys? Bioengineering organoids computational multiscale models stem cell organization disease modelling drug response |
| title | Organoid Cultures In Silico: Tools or Toys? |
| title_full | Organoid Cultures In Silico: Tools or Toys? |
| title_fullStr | Organoid Cultures In Silico: Tools or Toys? |
| title_full_unstemmed | Organoid Cultures In Silico: Tools or Toys? |
| title_short | Organoid Cultures In Silico: Tools or Toys? |
| title_sort | organoid cultures in silico tools or toys |
| topic | organoids computational multiscale models stem cell organization disease modelling drug response |
| url | https://www.mdpi.com/2306-5354/10/1/50 |
| work_keys_str_mv | AT torstenthalheim organoidculturesinsilicotoolsortoys AT gabrielaaust organoidculturesinsilicotoolsortoys AT joerggalle organoidculturesinsilicotoolsortoys |