Organoid Cultures In Silico: Tools or Toys?

Organoid Cultures In Silico: Tools or Toys?

The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of this culture system to support their theoretical appr...

Full description

Bibliographic Details
Main Authors:	Torsten Thalheim, Gabriela Aust, Joerg Galle
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Bioengineering
Subjects:	organoids computational multiscale models stem cell organization disease modelling drug response
Online Access:	https://www.mdpi.com/2306-5354/10/1/50

Similar Items

On the Cooperation between Epigenetics and Transcription Factor Networks in the Specification of Tissue Stem Cells
by: Torsten Thalheim, et al.
Published: (2018-10-01)

Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization of organoids
by: Hanbyeol Lee, et al.
Published: (2021-07-01)

Disease modeling in organoid cultures: a new tool for studying viruses
by: Jaewon Cho, et al.
Published: (2022-07-01)

The generation of glioma organoids and the comparison of two culture methods
by: Yang Zhang, et al.
Published: (2024-02-01)

Kidney organoids as a promising tool in nephrology
by: Mengyuan Wu, et al.
Published: (2022-05-01)

Advances in Cardiac Organoids
by: Yu-Hong Wang, et al.
Published: (2023-09-01)

Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease
by: Ania Bogoslowski, et al.
Published: (2023-08-01)

Protocol for generating human cerebral organoids from two-dimensional cultures of pluripotent stem cells bypassing embryoid body aggregation
by: Rosa González-Sastre, et al.
Published: (2025-03-01)

Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells
by: Fuad Gandhi Torizal, et al.
Published: (2024-10-01)

Organoids as complex (bio)systems
by: Tiago G. Fernandes, et al.
Published: (2023-08-01)

Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling
by: Weidong Shao, et al.
Published: (2025-01-01)

Protocol for generating embedding-free brain organoids enriched with oligodendrocytes
by: Bahaa Al-mhanawi, et al.
Published: (2023-12-01)

Kidney organoids: development and applications
by: Hye-Youn Kim, et al.
Published: (2023-06-01)

Protocol for the establishment and characterization of an endometrial-derived epithelial organoid and stromal cell co-culture system
by: Jason A. Rizo, et al.
Published: (2024-03-01)

Organoids: Construction and Application in Gastric Cancer
by: Chengdong Huo, et al.
Published: (2023-05-01)

Advancing Glioblastoma Research with Innovative Brain Organoid-Based Models
by: Cátia D. Correia, et al.
Published: (2025-02-01)

Kidney Organoids and Tubuloids
by: Fjodor A. Yousef Yengej, et al.
Published: (2020-05-01)

Protocol for cryopreserving neural organoids and human living brain tissue using MEDY
by: Weiwei Xue, et al.
Published: (2024-12-01)

Protocol for generating a pancreatic cancer organoid associated with heterogeneous tumor microenvironment
by: Kenta Takeuchi, et al.
Published: (2025-03-01)

Epigenetic Drifts during Long-Term Intestinal Organoid Culture
by: Torsten Thalheim, et al.
Published: (2021-07-01)

Protocol for whole-mount immunofluorescence staining of ECM gel-embedded innervated pancreatic organoids
by: Hüseyin Erdinç Beşikcioğlu, et al.
Published: (2024-06-01)

Gastrointestinal tract organoids as novel tools in drug discovery
by: Li Zhou, et al.
Published: (2024-08-01)

Recent advances and challenges in organoid-on-a-chip technology
by: Intan Rosalina Suhito, et al.
Published: (2022-04-01)

Hepatobiliary organoid research: the progress and applications
by: Rui-Qi Zou, et al.
Published: (2025-02-01)

A reference for selecting an appropriate method for generating glioblastoma organoids from the application perspective
by: Jing Liang, et al.
Published: (2024-09-01)

Utility of the Cerebral Organoid Glioma ‘GLICO’ Model for Screening Applications
by: Freya R. Weth, et al.
Published: (2022-12-01)

Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
by: Cleber A Trujillo, et al.
Published: (2020-12-01)

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems
by: Rita Silva-Pedrosa, et al.
Published: (2023-03-01)

Protocol for transplantation of cells derived from human midbrain organoids into a Parkinson’s disease mouse model to restore motor function
by: Chong-Lei Fu, et al.
Published: (2024-09-01)

Vascularized Tissue Organoids
by: Hannah A. Strobel, et al.
Published: (2023-01-01)

Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology
by: Mu Seog Choe, et al.
Published: (2024-04-01)

Gastric stem cell research and gastric organoids
by: Haengdueng Jeong, et al.
Published: (2022-12-01)

Progress and breakthroughs in human kidney organoid research
by: Qi Liu, et al.
Published: (2024-09-01)

Interactions of the Immune System with Human Kidney Organoids
by: Anusha S. Shankar, et al.
Published: (2024-04-01)

Current and Future Perspectives of the Use of Organoids in Radiobiology
by: Peter W. Nagle, et al.
Published: (2020-12-01)

Modelling Toxoplasma gondii infection in human cerebral organoids
by: Hyang-Hee Seo, et al.
Published: (2020-01-01)

Modeling, applications and challenges of inner ear organoid
by: Jieyu Qi, et al.
Published: (2024-02-01)

Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
by: Yushan Li, et al.
Published: (2024-06-01)

Editorial: Endocrine organoids for modeling, drug development, and treatment of cancer and other diseases
by: Vijaya Kumar Pidugu, et al.
Published: (2023-09-01)

Salivary gland organoid transplantation as a therapeutic option for radiation-induced xerostomia
by: Seong Gyeong Jeon, et al.
Published: (2024-08-01)