Identification of Zinc-Dependent Mechanisms Used by Group B <italic toggle="yes">Streptococcus</italic> To Overcome Calprotectin-Mediated Stress

Identification of Zinc-Dependent Mechanisms Used by Group B <italic toggle="yes">Streptococcus</italic> To Overcome Calprotectin-Mediated Stress

ABSTRACT Nutritional immunity is an elegant host mechanism used to starve invading pathogens of necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by neutrophils and is found in high concentrations within inflammatory sites during infection. Group B Streptococcu...

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Main Authors: Lindsey R. Burcham, Yoann Le Breton, Jana N. Radin, Brady L. Spencer, Liwen Deng, Aurélia Hiron, Monica R. Ransom, Jéssica da C. Mendonça, Ashton T. Belew, Najib M. El-Sayed, Kevin S. McIver, Thomas E. Kehl-Fie, Kelly S. Doran
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mBio
Subjects:
GBS
calprotectin
meningitis
nutritional immunity
zinc
Online Access:https://journals.asm.org/doi/10.1128/mBio.02302-20

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