STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-hel...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2017-10-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1364 |
| _version_ | 1826534228215463936 |
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| author | A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov |
| author_facet | A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov |
| author_sort | A. O. Kenkishvili |
| collection | DOAJ |
| description | We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-helper cytokines was changed (IL-2 was decreased along with increased IFNγ) accompanied by decreased allergen-specific IgG1, IgE and increased IgG2a in blood serum. At the stage of boosting the respiratory allergy, intravenous administration of QD caused reduction of inflammatory lung infiltration, and composition of bronchoalveolar lavage fluid was altered, i.e., IgG1 and IgE showed a decrease, along with higher IgG2a levels. |
| first_indexed | 2024-03-08T05:49:09Z |
| format | Article |
| id | doaj.art-d67d3d2f18cf4b69aed11cc0a6d0e9c6 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:19:41Z |
| publishDate | 2017-10-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-d67d3d2f18cf4b69aed11cc0a6d0e9c62025-03-11T17:59:08ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2017-10-0119562963410.15789/1563-0625-2017-5-629-634958STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICEA. O. Kenkishvili0D. Z. Albegova1O. S. Laptev2S. I. Pavlova3G. K. Albegova4I. G. Kozlov5Russian National N.I. Pirogov Research Medical University.Russian National N.I. Pirogov Research Medical University.Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology; Russian National N.I. Pirogov Research Medical University.Federal D. Rogachev Research and Clinical Center for Pediatric Hematology, Oncology and Immunology; Chuvash State I.N. Ulianov University.North Ossetia State Medical Academy, Ministry of Health Care.Russian National N.I. Pirogov Research Medical University; Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology.We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-helper cytokines was changed (IL-2 was decreased along with increased IFNγ) accompanied by decreased allergen-specific IgG1, IgE and increased IgG2a in blood serum. At the stage of boosting the respiratory allergy, intravenous administration of QD caused reduction of inflammatory lung infiltration, and composition of bronchoalveolar lavage fluid was altered, i.e., IgG1 and IgE showed a decrease, along with higher IgG2a levels.https://www.mimmun.ru/mimmun/article/view/1364flavonoidsrespiratory allergyimmunosuppression |
| spellingShingle | A. O. Kenkishvili D. Z. Albegova O. S. Laptev S. I. Pavlova G. K. Albegova I. G. Kozlov STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE Медицинская иммунология flavonoids respiratory allergy immunosuppression |
| title | STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE |
| title_full | STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE |
| title_fullStr | STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE |
| title_full_unstemmed | STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE |
| title_short | STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE |
| title_sort | study of quercetin dihydrate effects in a model of ova induced respiratory allergy in mice |
| topic | flavonoids respiratory allergy immunosuppression |
| url | https://www.mimmun.ru/mimmun/article/view/1364 |
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