| Summary: | Protein aggregates of cofilin and actin have been found in neurons under oxygen–glucose deprivation. However, the regulatory mechanism behind the expression of <i>Cfl1</i> during oxygen–glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of <i>Cfl1</i> mRNA, and formation of cofilin–actin aggregates. The interaction between hnRNP A1 and <i>Cfl1</i> mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of <i>Cfl1</i> mRNA under oxygen–glucose deprived conditions. These findings reveal a new translational regulatory mechanism of <i>Cfl1</i> mRNA in hippocampal neurons under oxygen–glucose deprivation.
|
|---|