hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons
Protein aggregates of cofilin and actin have been found in neurons under oxygen–glucose deprivation. However, the regulatory mechanism behind the expression of <i>Cfl1</i> during oxygen–glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnR...
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3567 |
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| author | Sung Wook Kim In Kyung Hong Mingee Kim Yun Seon Song Kyong-Tai Kim |
| author_facet | Sung Wook Kim In Kyung Hong Mingee Kim Yun Seon Song Kyong-Tai Kim |
| author_sort | Sung Wook Kim |
| collection | DOAJ |
| description | Protein aggregates of cofilin and actin have been found in neurons under oxygen–glucose deprivation. However, the regulatory mechanism behind the expression of <i>Cfl1</i> during oxygen–glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of <i>Cfl1</i> mRNA, and formation of cofilin–actin aggregates. The interaction between hnRNP A1 and <i>Cfl1</i> mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of <i>Cfl1</i> mRNA under oxygen–glucose deprived conditions. These findings reveal a new translational regulatory mechanism of <i>Cfl1</i> mRNA in hippocampal neurons under oxygen–glucose deprivation. |
| first_indexed | 2024-03-10T04:25:15Z |
| format | Article |
| id | doaj.art-d67d5b1c031d41f1b6859e93030004ba |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:15Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d67d5b1c031d41f1b6859e93030004ba2023-11-23T07:39:35ZengMDPI AGCells2073-44092021-12-011012356710.3390/cells10123567hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal NeuronsSung Wook Kim0In Kyung Hong1Mingee Kim2Yun Seon Song3Kyong-Tai Kim4Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul 04310, KoreaDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, KoreaProtein aggregates of cofilin and actin have been found in neurons under oxygen–glucose deprivation. However, the regulatory mechanism behind the expression of <i>Cfl1</i> during oxygen–glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of <i>Cfl1</i> mRNA, and formation of cofilin–actin aggregates. The interaction between hnRNP A1 and <i>Cfl1</i> mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of <i>Cfl1</i> mRNA under oxygen–glucose deprived conditions. These findings reveal a new translational regulatory mechanism of <i>Cfl1</i> mRNA in hippocampal neurons under oxygen–glucose deprivation.https://www.mdpi.com/2073-4409/10/12/3567oxygen–glucose deprivationcofilin–actin aggregatesmRNA translationneurodegenerationRNA-binding proteins |
| spellingShingle | Sung Wook Kim In Kyung Hong Mingee Kim Yun Seon Song Kyong-Tai Kim hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons Cells oxygen–glucose deprivation cofilin–actin aggregates mRNA translation neurodegeneration RNA-binding proteins |
| title | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons |
| title_full | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons |
| title_fullStr | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons |
| title_full_unstemmed | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons |
| title_short | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons |
| title_sort | hnrnp q and hnrnp a1 regulate the translation of cofilin in response to transient oxygen glucose deprivation in hippocampal neurons |
| topic | oxygen–glucose deprivation cofilin–actin aggregates mRNA translation neurodegeneration RNA-binding proteins |
| url | https://www.mdpi.com/2073-4409/10/12/3567 |
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