Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life wit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1921 |
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| author | Pierluigi Marzuillo Pier Luigi Palma Anna Di Sessa Agnese Roberti Giovanni Torino Maeva De Lucia Emanuele Miraglia del Giudice Stefano Guarino Giovanni Di Iorio |
| author_facet | Pierluigi Marzuillo Pier Luigi Palma Anna Di Sessa Agnese Roberti Giovanni Torino Maeva De Lucia Emanuele Miraglia del Giudice Stefano Guarino Giovanni Di Iorio |
| author_sort | Pierluigi Marzuillo |
| collection | DOAJ |
| description | The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life with suspected obstructive CAKUT were prospectively enrolled. The patients underwent a 2-year follow-up and were classified as patients needing or not needing surgery. In all of the enrolled patients, PRA and serum aldosterone levels were measured at 1–3 months of life and were evaluated as predictors of surgery by receiver-operating characteristic (ROC) curve analysis. Patients undergoing surgery during follow-up showed significantly higher levels of aldosterone at 1–3 months of life compared to those who did not require surgery (<i>p</i> = 0.006). The ROC curve analysis of the aldosterone for obstructive CAKUT needing surgery showed an area under the ROC curve of 0.88 (95%CI = 0.71–0.95; <i>p</i> = 0.001). The aldosterone cut-off of 100 ng/dL presented 100% sensitivity and 64.3% specificity and predicted surgery in 100% of cases. The PRA at 1–3 months of life was not a predictor of surgery. In conclusion, serum aldosterone levels at 1–3 months could predict the need for surgery during obstructive CAKUT follow-up. |
| first_indexed | 2024-03-11T07:20:58Z |
| format | Article |
| id | doaj.art-d67fe68591aa4cc6b962e65964857ccc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:20:58Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d67fe68591aa4cc6b962e65964857ccc2023-11-17T08:00:12ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125192110.3390/jcm12051921Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot StudyPierluigi Marzuillo0Pier Luigi Palma1Anna Di Sessa2Agnese Roberti3Giovanni Torino4Maeva De Lucia5Emanuele Miraglia del Giudice6Stefano Guarino7Giovanni Di Iorio8Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPediatric Urology Unit, “Santobono-Pausilipon” Children’s Hospital, 80129 Naples, ItalyPediatric Urology Unit, “Santobono-Pausilipon” Children’s Hospital, 80129 Naples, ItalyDepartment of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPediatric Urology Unit, “Santobono-Pausilipon” Children’s Hospital, 80129 Naples, ItalyThe aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life with suspected obstructive CAKUT were prospectively enrolled. The patients underwent a 2-year follow-up and were classified as patients needing or not needing surgery. In all of the enrolled patients, PRA and serum aldosterone levels were measured at 1–3 months of life and were evaluated as predictors of surgery by receiver-operating characteristic (ROC) curve analysis. Patients undergoing surgery during follow-up showed significantly higher levels of aldosterone at 1–3 months of life compared to those who did not require surgery (<i>p</i> = 0.006). The ROC curve analysis of the aldosterone for obstructive CAKUT needing surgery showed an area under the ROC curve of 0.88 (95%CI = 0.71–0.95; <i>p</i> = 0.001). The aldosterone cut-off of 100 ng/dL presented 100% sensitivity and 64.3% specificity and predicted surgery in 100% of cases. The PRA at 1–3 months of life was not a predictor of surgery. In conclusion, serum aldosterone levels at 1–3 months could predict the need for surgery during obstructive CAKUT follow-up.https://www.mdpi.com/2077-0383/12/5/1921congenital anomalies of the kidney and urinary tracturinary tract obstructionposterior urethral valvesureteropelvic junction obstructionprimary megaureteraldosterone |
| spellingShingle | Pierluigi Marzuillo Pier Luigi Palma Anna Di Sessa Agnese Roberti Giovanni Torino Maeva De Lucia Emanuele Miraglia del Giudice Stefano Guarino Giovanni Di Iorio Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study Journal of Clinical Medicine congenital anomalies of the kidney and urinary tract urinary tract obstruction posterior urethral valves ureteropelvic junction obstruction primary megaureter aldosterone |
| title | Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study |
| title_full | Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study |
| title_fullStr | Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study |
| title_full_unstemmed | Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study |
| title_short | Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study |
| title_sort | early in life serum aldosterone levels could predict surgery in patients with obstructive congenital anomalies of the kidney and urinary tract a pilot study |
| topic | congenital anomalies of the kidney and urinary tract urinary tract obstruction posterior urethral valves ureteropelvic junction obstruction primary megaureter aldosterone |
| url | https://www.mdpi.com/2077-0383/12/5/1921 |
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