Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures
Abstract Background Few studies have examined the relationship between perioperative blood transfusion (PBT) and length of hospital stay (LOS) in patients with osteoporotic fractures. This research aims to study the association between PBT and LOS. Methods This is a retrospective cross-sectional stu...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-023-07101-6 |
| _version_ | 1827399751401734144 |
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| author | Si-ming Xu Ke Lu Xu-feng Yang Yao-wei Ye Min-zhe Xu Qin Shi Ya-qin Gong Chong Li |
| author_facet | Si-ming Xu Ke Lu Xu-feng Yang Yao-wei Ye Min-zhe Xu Qin Shi Ya-qin Gong Chong Li |
| author_sort | Si-ming Xu |
| collection | DOAJ |
| description | Abstract Background Few studies have examined the relationship between perioperative blood transfusion (PBT) and length of hospital stay (LOS) in patients with osteoporotic fractures. This research aims to study the association between PBT and LOS. Methods This is a retrospective cross-sectional study from the Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China, involving 2357 osteoporotic fractures (OPF) patients who received surgical treatment during hospitalization from January 2017 and March 2022. Multiple linear regression was used to analyze the relationship between PBT and LOS. In the analysis, PBT volume was the dependent variable, whereas LOS was the independent variable. Simultaneously, age, gender, body mass index, hemoglobin, primary diagnosis, American Society of Anesthesiologists, creatinine (Cr), anesthesia, surgical method, and Charlson comorbidity index were included as covariates. The generalized additive model was then used to study nonlinear associations. Two piecewise linear regression exemplary evaluated the inception results for smoothing the curve. Results Our results proved that PBT was positively correlated with LOS in the fully adjusted model (β, 0.21; 95% CI, 0.04 to 0.37; P < 0.0001). Furthermore, a “U-shape” nonlinear relationship existed between PBT and LOS. When the concentration of PBT was between 0 and 1.5 units, it was manifested as a negative correlation between PBT and LOS. However, there was a positive association between PBT and LOS when PBT levels exceeded 1.5 units. Conclusions This study demonstrated that PBT and LOS in the OPF population were independent with a nonlinear relationship. These results suggest that PBT may be protective for patients with long LOS. If these findings are confirmed, the LOS in OPF patients can be regulated through appropriate perioperative blood transfusion. |
| first_indexed | 2024-03-08T19:50:43Z |
| format | Article |
| id | doaj.art-d680b644509544a2bbee1ed9a61e795f |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-08T19:50:43Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-d680b644509544a2bbee1ed9a61e795f2023-12-24T12:07:41ZengBMCBMC Musculoskeletal Disorders1471-24742023-12-0124111110.1186/s12891-023-07101-6Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fracturesSi-ming Xu0Ke Lu1Xu-feng Yang2Yao-wei Ye3Min-zhe Xu4Qin Shi5Ya-qin Gong6Chong Li7Department of Orthopedics, Gusu School, Nanjing Medical University, The First People’s Hospital of KunshanDepartment of Orthopedics, Affiliated Kunshan Hospital of Jiangsu UniversityDepartment of Orthopedics, Affiliated Kunshan Hospital of Jiangsu UniversityDepartment of Orthopedics, Gusu School, Nanjing Medical University, The First People’s Hospital of KunshanDepartment of Orthopedics, Affiliated Kunshan Hospital of Jiangsu UniversityDepartment of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow UniversityInformation Department, Affiliated Kunshan Hospital of Jiangsu UniversityDepartment of Orthopedics, Gusu School, Nanjing Medical University, The First People’s Hospital of KunshanAbstract Background Few studies have examined the relationship between perioperative blood transfusion (PBT) and length of hospital stay (LOS) in patients with osteoporotic fractures. This research aims to study the association between PBT and LOS. Methods This is a retrospective cross-sectional study from the Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China, involving 2357 osteoporotic fractures (OPF) patients who received surgical treatment during hospitalization from January 2017 and March 2022. Multiple linear regression was used to analyze the relationship between PBT and LOS. In the analysis, PBT volume was the dependent variable, whereas LOS was the independent variable. Simultaneously, age, gender, body mass index, hemoglobin, primary diagnosis, American Society of Anesthesiologists, creatinine (Cr), anesthesia, surgical method, and Charlson comorbidity index were included as covariates. The generalized additive model was then used to study nonlinear associations. Two piecewise linear regression exemplary evaluated the inception results for smoothing the curve. Results Our results proved that PBT was positively correlated with LOS in the fully adjusted model (β, 0.21; 95% CI, 0.04 to 0.37; P < 0.0001). Furthermore, a “U-shape” nonlinear relationship existed between PBT and LOS. When the concentration of PBT was between 0 and 1.5 units, it was manifested as a negative correlation between PBT and LOS. However, there was a positive association between PBT and LOS when PBT levels exceeded 1.5 units. Conclusions This study demonstrated that PBT and LOS in the OPF population were independent with a nonlinear relationship. These results suggest that PBT may be protective for patients with long LOS. If these findings are confirmed, the LOS in OPF patients can be regulated through appropriate perioperative blood transfusion.https://doi.org/10.1186/s12891-023-07101-6Perioperative blood transfusionLength of hospital stayOsteoporotic fracture |
| spellingShingle | Si-ming Xu Ke Lu Xu-feng Yang Yao-wei Ye Min-zhe Xu Qin Shi Ya-qin Gong Chong Li Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures BMC Musculoskeletal Disorders Perioperative blood transfusion Length of hospital stay Osteoporotic fracture |
| title | Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| title_full | Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| title_fullStr | Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| title_full_unstemmed | Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| title_short | Association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| title_sort | association between perioperative blood transfusion and length of hospital stay in patients with osteoporotic fractures |
| topic | Perioperative blood transfusion Length of hospital stay Osteoporotic fracture |
| url | https://doi.org/10.1186/s12891-023-07101-6 |
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