Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19959-4 |
| _version_ | 1818433625638567936 |
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| author | Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn |
| author_facet | Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn |
| author_sort | Jared S. Mackenzie |
| collection | DOAJ |
| description | Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted. |
| first_indexed | 2024-12-14T16:24:04Z |
| format | Article |
| id | doaj.art-d680f868a7c742a69cdc3f6e9206d15b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:24:04Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d680f868a7c742a69cdc3f6e9206d15b2022-12-21T22:54:44ZengNature PortfolioNature Communications2041-17232020-11-0111111610.1038/s41467-020-19959-4Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosisJared S. Mackenzie0Dirk A. Lamprecht1Rukaya Asmal2John H. Adamson3Khushboo Borah4Dany J. V. Beste5Bei Shi Lee6Kevin Pethe7Simon Rousseau8Inna Krieger9James C. Sacchettini10Joel N. Glasgow11Adrie J. C. Steyn12Africa Health Research InstituteJanssen Pharmaceutica, Global Public HealthAfrica Health Research InstituteAfrica Health Research InstituteFaculty of Health and Medical Sciences, University of SurreyFaculty of Health and Medical Sciences, University of SurreySchool of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversityTexas A&M University, Department of Biochemistry and BiophysicsTexas A&M University, Department of Biochemistry and BiophysicsTexas A&M University, Department of Biochemistry and BiophysicsDepartment of Microbiology, University of Alabama at BirminghamAfrica Health Research InstituteBedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative phosphorylation is also targeted.https://doi.org/10.1038/s41467-020-19959-4 |
| spellingShingle | Jared S. Mackenzie Dirk A. Lamprecht Rukaya Asmal John H. Adamson Khushboo Borah Dany J. V. Beste Bei Shi Lee Kevin Pethe Simon Rousseau Inna Krieger James C. Sacchettini Joel N. Glasgow Adrie J. C. Steyn Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis Nature Communications |
| title | Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis |
| title_full | Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis |
| title_fullStr | Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis |
| title_full_unstemmed | Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis |
| title_short | Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis |
| title_sort | bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in mycobacterium tuberculosis |
| url | https://doi.org/10.1038/s41467-020-19959-4 |
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