A Comparative Systematic Review of COVID-19 and Influenza
Background: Both SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings. Methods: Literature search was done using PubMed to find MEDLINE indexed articles relevant to this study. As of 25 November 2020, the search has been condu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/3/452 |
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| author | Molka Osman Timothée Klopfenstein Nabil Belfeki Vincent Gendrin Souheil Zayet |
| author_facet | Molka Osman Timothée Klopfenstein Nabil Belfeki Vincent Gendrin Souheil Zayet |
| author_sort | Molka Osman |
| collection | DOAJ |
| description | Background: Both SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings. Methods: Literature search was done using PubMed to find MEDLINE indexed articles relevant to this study. As of 25 November 2020, the search has been conducted by combining the MeSH words “COVID-19” and “Influenza”. Results: Eighteen articles were finally selected in adult patients. Comorbidities such as cardiovascular diseases, diabetes, and obesity were significantly higher in COVID-19 patients, while pulmonary diseases and immunocompromised conditions were significantly more common in influenza patients. The incidence rates of fever, vomiting, ocular and otorhinolaryngological symptoms were found to be significantly higher in influenza patients when compared with COVID-19 patients. However, neurologic symptoms and diarrhea were statistically more frequent in COVID-19 patients. The level of white cell count and procalcitonin was significantly higher in influenza patients, whereas thrombopenia and elevated transaminases were significantly more common in COVID-19 patients. Ground-grass opacities, interlobular septal thickening, and a peripheral distribution were more common in COVID-19 patients than in influenza patients where consolidations and linear opacities were described instead. COVID-19 patients were significantly more often transferred to intensive care unit with a higher rate of mortality. Conclusions: This study estimated differences of COVID-19 and influenza patients which can help clinicians during the co-circulation of the two viruses. |
| first_indexed | 2024-03-10T13:22:42Z |
| format | Article |
| id | doaj.art-d6817fb1689e4107a6e1f1c5ad7595d4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T13:22:42Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d6817fb1689e4107a6e1f1c5ad7595d42023-11-21T09:57:19ZengMDPI AGViruses1999-49152021-03-0113345210.3390/v13030452A Comparative Systematic Review of COVID-19 and InfluenzaMolka Osman0Timothée Klopfenstein1Nabil Belfeki2Vincent Gendrin3Souheil Zayet4Faculty of Medicine of Tunis, University Tunis El Manar, Tunis 1007, TunisiaInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trévenans, FranceInternal Medicine Department, Groupe Hospitalier Sud Ile de France, 77000 Melun, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trévenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trévenans, FranceBackground: Both SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings. Methods: Literature search was done using PubMed to find MEDLINE indexed articles relevant to this study. As of 25 November 2020, the search has been conducted by combining the MeSH words “COVID-19” and “Influenza”. Results: Eighteen articles were finally selected in adult patients. Comorbidities such as cardiovascular diseases, diabetes, and obesity were significantly higher in COVID-19 patients, while pulmonary diseases and immunocompromised conditions were significantly more common in influenza patients. The incidence rates of fever, vomiting, ocular and otorhinolaryngological symptoms were found to be significantly higher in influenza patients when compared with COVID-19 patients. However, neurologic symptoms and diarrhea were statistically more frequent in COVID-19 patients. The level of white cell count and procalcitonin was significantly higher in influenza patients, whereas thrombopenia and elevated transaminases were significantly more common in COVID-19 patients. Ground-grass opacities, interlobular septal thickening, and a peripheral distribution were more common in COVID-19 patients than in influenza patients where consolidations and linear opacities were described instead. COVID-19 patients were significantly more often transferred to intensive care unit with a higher rate of mortality. Conclusions: This study estimated differences of COVID-19 and influenza patients which can help clinicians during the co-circulation of the two viruses.https://www.mdpi.com/1999-4915/13/3/452influenzaCOVID-19SARS-CoV-2clinical featureslaboratoryimaging |
| spellingShingle | Molka Osman Timothée Klopfenstein Nabil Belfeki Vincent Gendrin Souheil Zayet A Comparative Systematic Review of COVID-19 and Influenza Viruses influenza COVID-19 SARS-CoV-2 clinical features laboratory imaging |
| title | A Comparative Systematic Review of COVID-19 and Influenza |
| title_full | A Comparative Systematic Review of COVID-19 and Influenza |
| title_fullStr | A Comparative Systematic Review of COVID-19 and Influenza |
| title_full_unstemmed | A Comparative Systematic Review of COVID-19 and Influenza |
| title_short | A Comparative Systematic Review of COVID-19 and Influenza |
| title_sort | comparative systematic review of covid 19 and influenza |
| topic | influenza COVID-19 SARS-CoV-2 clinical features laboratory imaging |
| url | https://www.mdpi.com/1999-4915/13/3/452 |
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