Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers
It has been proved that Silymarin is effective in prevention and treatment of human liver diseases such as cirrhosis. Therefore, the objective of this study was to evaluate the preventive effects of Silymarin extract as a food additive on hepatotoxicity induced by carbon tetrachloride in broilers. N...
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| Format: | Article |
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Islamic Azad University, Tabriz Branch
2014-08-01
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| Series: | Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī |
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| Online Access: | http://jvcp.iaut.ac.ir/article_517163_e9e9f7585d0665a75810ff8d86ec30ac.pdf |
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| author | mohammadreza Mohammadi Malayeri abolfazl Dadkhah Tehrani amir Rezaei |
| author_facet | mohammadreza Mohammadi Malayeri abolfazl Dadkhah Tehrani amir Rezaei |
| author_sort | mohammadreza Mohammadi Malayeri |
| collection | DOAJ |
| description | It has been proved that Silymarin is effective in prevention and treatment of human liver diseases such as cirrhosis. Therefore, the objective of this study was to evaluate the preventive effects of Silymarin extract as a food additive on hepatotoxicity induced by carbon tetrachloride in broilers. Ninety broiler chickens were randomly assigned to 9 equal study groups as follow: negative control, positive control which were injected 2ml/kg BW (body weight) ccl4 dissolved in olive oil (1:1) via IP in the 24th and 26th days, olive oil control, treatment controls which were receiving 3,6 and 10 mg/kg BW silymarin in 1ml olive oil respectively by gavage from the 21st up to 26th days and treatment groups which received ccl4 and 3,6 and 10 mg/kg BW silymarin extract respectively. Blood and liver samples were collected to assay ALT, AST and ALP activities as well as pathological changes. The Data were analyzed using ANOVA method by SPSS. The results revealed that carbon tetrachloride significantly increased ALT,AST and ALP activities in comparison with the negative control group (p |
| first_indexed | 2024-12-11T01:09:03Z |
| format | Article |
| id | doaj.art-d682402bcd5d47d381f9e9edcb3a8900 |
| institution | Directory Open Access Journal |
| issn | 2322-4746 2476-6984 |
| language | fas |
| last_indexed | 2024-12-11T01:09:03Z |
| publishDate | 2014-08-01 |
| publisher | Islamic Azad University, Tabriz Branch |
| record_format | Article |
| series | Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī |
| spelling | doaj.art-d682402bcd5d47d381f9e9edcb3a89002022-12-22T01:26:06ZfasIslamic Azad University, Tabriz BranchĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī2322-47462476-69842014-08-0182 (30) تابستان445459517163Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilersmohammadreza Mohammadi Malayeri0abolfazl Dadkhah Tehrani1amir Rezaei2استادیار گروه پاتوبیولوژی، دانشکده دامپزشکی، واحد گرمسار، دانشگاه آزاد اسلامی، گرمسار، ایران.استادیار گروه علوم پایه، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران.دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، واحد گرمسار، دانشگاه آزاد اسلامی، گرمسار، ایران.It has been proved that Silymarin is effective in prevention and treatment of human liver diseases such as cirrhosis. Therefore, the objective of this study was to evaluate the preventive effects of Silymarin extract as a food additive on hepatotoxicity induced by carbon tetrachloride in broilers. Ninety broiler chickens were randomly assigned to 9 equal study groups as follow: negative control, positive control which were injected 2ml/kg BW (body weight) ccl4 dissolved in olive oil (1:1) via IP in the 24th and 26th days, olive oil control, treatment controls which were receiving 3,6 and 10 mg/kg BW silymarin in 1ml olive oil respectively by gavage from the 21st up to 26th days and treatment groups which received ccl4 and 3,6 and 10 mg/kg BW silymarin extract respectively. Blood and liver samples were collected to assay ALT, AST and ALP activities as well as pathological changes. The Data were analyzed using ANOVA method by SPSS. The results revealed that carbon tetrachloride significantly increased ALT,AST and ALP activities in comparison with the negative control group (phttp://jvcp.iaut.ac.ir/article_517163_e9e9f7585d0665a75810ff8d86ec30ac.pdfHepatotoxicityCarbon tetrachloridebroilerssilymarin |
| spellingShingle | mohammadreza Mohammadi Malayeri abolfazl Dadkhah Tehrani amir Rezaei Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī Hepatotoxicity Carbon tetrachloride broilers silymarin |
| title | Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers |
| title_full | Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers |
| title_fullStr | Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers |
| title_full_unstemmed | Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers |
| title_short | Preventive effects of silymarin extract on carbon tetrachloride-induced hepatotoxicity in broilers |
| title_sort | preventive effects of silymarin extract on carbon tetrachloride induced hepatotoxicity in broilers |
| topic | Hepatotoxicity Carbon tetrachloride broilers silymarin |
| url | http://jvcp.iaut.ac.ir/article_517163_e9e9f7585d0665a75810ff8d86ec30ac.pdf |
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