Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome

Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome

Fragile X Syndrome (FXS) is a neurodevelopmental disorder instigated by the absence of a key translation regulating protein, Fragile X Mental Retardation Protein (FMRP). The loss of FMRP in the CNS leads to abnormal synaptic development, disruption of critical periods of plasticity, and an overall d...

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Bibliographic Details
Main Authors: C.A. Cea-Del Rio, A. Nunez-Parra, S.M. Freedman, J.K. Kushner, A.L. Alexander, D. Restrepo, M.M. Huntsman
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Neurobiology of Disease
Subjects:
Inhibitory neurotransmission
Plasticity
Fragile X syndrome
Interneurons
Cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302345

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