Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2021.1902754 |
| _version_ | 1818501372747710464 |
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| author | Nannan Wu Jia Dai Mingquan Guo Jianhui Li Xin Zhou Feng Li Yuan Gao Hongping Qu Hongzhou Lu Jing Jin Tao Li Lei Shi Qingguo Wu Ruoming Tan Mingli Zhu Lan Yang Yun Ling Shunpeng Xing Jianzhong Zhang Bangxin Yao Shuai Le Jingmin Gu Jinhong Qin Jie Li Mengjun Cheng Demeng Tan Linlin Li Yiyuan Zhang Zhaoqin Zhu Jinfeng Cai Zhigang Song Xiaokui Guo Li-Kuang Chen Tongyu Zhu |
| author_facet | Nannan Wu Jia Dai Mingquan Guo Jianhui Li Xin Zhou Feng Li Yuan Gao Hongping Qu Hongzhou Lu Jing Jin Tao Li Lei Shi Qingguo Wu Ruoming Tan Mingli Zhu Lan Yang Yun Ling Shunpeng Xing Jianzhong Zhang Bangxin Yao Shuai Le Jingmin Gu Jinhong Qin Jie Li Mengjun Cheng Demeng Tan Linlin Li Yiyuan Zhang Zhaoqin Zhu Jinfeng Cai Zhigang Song Xiaokui Guo Li-Kuang Chen Tongyu Zhu |
| author_sort | Nannan Wu |
| collection | DOAJ |
| description | Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 109 plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients. |
| first_indexed | 2024-12-10T20:55:14Z |
| format | Article |
| id | doaj.art-d684f17ee90d4c13b9b374ff2d9e2c9a |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-12-10T20:55:14Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-d684f17ee90d4c13b9b374ff2d9e2c9a2022-12-22T01:33:58ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-0110161261810.1080/22221751.2021.1902754Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patientsNannan Wu0Jia Dai1Mingquan Guo2Jianhui Li3Xin Zhou4Feng Li5Yuan Gao6Hongping Qu7Hongzhou Lu8Jing Jin9Tao Li10Lei Shi11Qingguo Wu12Ruoming Tan13Mingli Zhu14Lan Yang15Yun Ling16Shunpeng Xing17Jianzhong Zhang18Bangxin Yao19Shuai Le20Jingmin Gu21Jinhong Qin22Jie Li23Mengjun Cheng24Demeng Tan25Linlin Li26Yiyuan Zhang27Zhaoqin Zhu28Jinfeng Cai29Zhigang Song30Xiaokui Guo31Li-Kuang Chen32Tongyu Zhu33Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Respiratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Shanghai, People’s Republic of ChinaXituo Biotechnology Co., Ltd, Zhengzhou, People’s Republic of ChinaDepartment of Tuberculosis, Shanghai public health clinical center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Hospital Infection Management, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Respiratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaDepartment of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaDepartment of Pharmacy, Zhongshan Hospital Fudan University, Shanghai, People’s Republic of ChinaDepartment of Pharmacy, Zhongshan Hospital Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Center, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaShanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaPhage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 109 plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.https://www.tandfonline.com/doi/10.1080/22221751.2021.1902754Phage therapycarbapenem-resistant Acinetobacter baumanniinosocomial infectionsCOVID-19 |
| spellingShingle | Nannan Wu Jia Dai Mingquan Guo Jianhui Li Xin Zhou Feng Li Yuan Gao Hongping Qu Hongzhou Lu Jing Jin Tao Li Lei Shi Qingguo Wu Ruoming Tan Mingli Zhu Lan Yang Yun Ling Shunpeng Xing Jianzhong Zhang Bangxin Yao Shuai Le Jingmin Gu Jinhong Qin Jie Li Mengjun Cheng Demeng Tan Linlin Li Yiyuan Zhang Zhaoqin Zhu Jinfeng Cai Zhigang Song Xiaokui Guo Li-Kuang Chen Tongyu Zhu Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients Emerging Microbes and Infections Phage therapy carbapenem-resistant Acinetobacter baumannii nosocomial infections COVID-19 |
| title | Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients |
| title_full | Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients |
| title_fullStr | Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients |
| title_full_unstemmed | Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients |
| title_short | Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients |
| title_sort | pre optimized phage therapy on secondary acinetobacter baumannii infection in four critical covid 19 patients |
| topic | Phage therapy carbapenem-resistant Acinetobacter baumannii nosocomial infections COVID-19 |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2021.1902754 |
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