A Simple Flow Injection Analysis–Tandem Mass Spectrometry Method to Reduce False Positives of C5-Acylcarnitines Due to Pivaloylcarnitine Using Reference Ions

A Simple Flow Injection Analysis–Tandem Mass Spectrometry Method to Reduce False Positives of C5-Acylcarnitines Due to Pivaloylcarnitine Using Reference Ions

Flow injection analysis–tandem mass spectrometry (FIA-TMS) has been applied in a first-tier test of newborn screening (NBS). Although isovalerylcarnitine (i-C5), which is a diagnostic indicator of isovaleric acidemia (IVA), is isobaric with pivaloylcarnitine (p-C5), 2-methylbutyrylcarnitine, and n-v...

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Bibliographic Details
Main Authors: Takanari Hattori, Yoshitomo Notsu, Misa Tanaka, Miki Matsui, Tetsuo Iida, Jun Watanabe, Yoshimitsu Osawa, Seiji Yamaguchi, Shozo Yano, Takeshi Taketani, Hironori Kobayashi
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Children
Subjects:
isovaleric acidemia
newborn screening
false positive
C5-acylcarnitine
isovalerylcarnitine
pivaloylcarnitine
Online Access:https://www.mdpi.com/2227-9067/9/5/694

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