BET-inhibitor DYB-41 reduces pulmonary inflammation and local and systemic cytokine levels in LPS-induced acute respiratory distress syndrome: an experimental rodent study

BET-inhibitor DYB-41 reduces pulmonary inflammation and local and systemic cytokine levels in LPS-induced acute respiratory distress syndrome: an experimental rodent study

Abstract Background Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal motif (BET) inhibitors are a class of medications that selectively bind t...

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Bibliographic Details
Main Authors: Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger, Matthias Haenggi
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:Intensive Care Medicine Experimental
Subjects:
ARDS
BET-inhibitor
Acute lung injury
Lung fibrosis
Online Access:https://doi.org/10.1186/s40635-024-00604-z

Internet

https://doi.org/10.1186/s40635-024-00604-z

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