Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary
Background: Among orthopedic surgery materials, poly (methyl methacrylate) (PMMA) is most commonly used for its excellent mechanical properties and rapid self-setting time. However, PMMA bone cement has been reported to cause thermal necrosis and to have poor bioactivity, which must be improved. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417022000907 |
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| author | Yang Wei Nareshkumar Baskaran Huey-Yuan Wang Yu-Chieh Su Sasza Chyntara Nabilla Ren-Jei Chung |
| author_facet | Yang Wei Nareshkumar Baskaran Huey-Yuan Wang Yu-Chieh Su Sasza Chyntara Nabilla Ren-Jei Chung |
| author_sort | Yang Wei |
| collection | DOAJ |
| description | Background: Among orthopedic surgery materials, poly (methyl methacrylate) (PMMA) is most commonly used for its excellent mechanical properties and rapid self-setting time. However, PMMA bone cement has been reported to cause thermal necrosis and to have poor bioactivity, which must be improved. In contrast, tricalcium silicate (TCS), the most significant component of Portland Cement and the most effective bone cement material, might not always meet the needs of the cement due to its poor mechanical properties and elevated pH levels during hydration. We hypothesize that the benefits of both PMMA and TCS can be harnessed by mixing them together in different proportions. This would represent a better solution for the issues faced when using them alone. Methods: We, therefore, prepared a novel organic-inorganic PMMA/TCS composite bone cement mixing PMMA and different amounts of TCS and tested its effect on the biophysical properties. Results: The addition of 30% TCS reduced the exothermic temperature and pH variation during cement setting and hydration processes. However, the mechanical and handling properties of the bioactive PMMA/TCS composite were not affected. The in vitro study also revealed that the composite materials had higher cell viability than pure PMMA and TCS. Also, the in vivo study on animals indicated that the composite materials were more capable of forming bone, which further reinforced the biocompatibility of the proposed PMMA/TCS bone cement. Conclusion: By combining the advantages of each component, it could be possible to construct a more effective composite bone cement material. This would meet the needs of implantation material for orthopedic surgeries or a possible bone filler. |
| first_indexed | 2024-03-13T02:36:45Z |
| format | Article |
| id | doaj.art-d68716ac91f8431b9c74b60c8926ef7a |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-03-13T02:36:45Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-d68716ac91f8431b9c74b60c8926ef7a2023-06-29T04:14:25ZengElsevierBiomedical Journal2319-41702023-06-01463100540Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentaryYang Wei0Nareshkumar Baskaran1Huey-Yuan Wang2Yu-Chieh Su3Sasza Chyntara Nabilla4Ren-Jei Chung5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, TaiwanDepartment of Stomatology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, TaiwanDepartment of Materials, University of Oxford, Oxford, United KingdomDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan; Corresponding author. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), 1 Sec. 3, Zhongxiao E. Rd., Taipei, 10608, Taiwan.Background: Among orthopedic surgery materials, poly (methyl methacrylate) (PMMA) is most commonly used for its excellent mechanical properties and rapid self-setting time. However, PMMA bone cement has been reported to cause thermal necrosis and to have poor bioactivity, which must be improved. In contrast, tricalcium silicate (TCS), the most significant component of Portland Cement and the most effective bone cement material, might not always meet the needs of the cement due to its poor mechanical properties and elevated pH levels during hydration. We hypothesize that the benefits of both PMMA and TCS can be harnessed by mixing them together in different proportions. This would represent a better solution for the issues faced when using them alone. Methods: We, therefore, prepared a novel organic-inorganic PMMA/TCS composite bone cement mixing PMMA and different amounts of TCS and tested its effect on the biophysical properties. Results: The addition of 30% TCS reduced the exothermic temperature and pH variation during cement setting and hydration processes. However, the mechanical and handling properties of the bioactive PMMA/TCS composite were not affected. The in vitro study also revealed that the composite materials had higher cell viability than pure PMMA and TCS. Also, the in vivo study on animals indicated that the composite materials were more capable of forming bone, which further reinforced the biocompatibility of the proposed PMMA/TCS bone cement. Conclusion: By combining the advantages of each component, it could be possible to construct a more effective composite bone cement material. This would meet the needs of implantation material for orthopedic surgeries or a possible bone filler.http://www.sciencedirect.com/science/article/pii/S2319417022000907Tricalcium silicateBone cementPolymethylmethacrylateOrganic-inorganic composite |
| spellingShingle | Yang Wei Nareshkumar Baskaran Huey-Yuan Wang Yu-Chieh Su Sasza Chyntara Nabilla Ren-Jei Chung Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary Biomedical Journal Tricalcium silicate Bone cement Polymethylmethacrylate Organic-inorganic composite |
| title | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary |
| title_full | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary |
| title_fullStr | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary |
| title_full_unstemmed | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary |
| title_short | Study of polymethylmethacrylate/tricalcium silicate composite cement for orthopedic applicationAt a glance commentary |
| title_sort | study of polymethylmethacrylate tricalcium silicate composite cement for orthopedic applicationat a glance commentary |
| topic | Tricalcium silicate Bone cement Polymethylmethacrylate Organic-inorganic composite |
| url | http://www.sciencedirect.com/science/article/pii/S2319417022000907 |
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