Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.

Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.

Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 produ...

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Main Authors: Sixto M Leal, Sanhita Roy, Chairut Vareechon, Steven deJesus Carrion, Heather Clark, Manuel S Lopez-Berges, Antonio Di Pietro, Marcus Schrettl, Nicola Beckmann, Bernhard Redl, Hubertus Haas, Eric Pearlman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23853581/?tool=EBI

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