Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients

Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) can cause adverse pregnancy outcomes, such as spontaneous preterm delivery and stillbirth. It is a complex disease influenced by multiple factors, including genetics and the environment. Previous studies have reported that functioning n...

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Bibliographic Details
Main Authors: Hua Lai, Xianxian Liu, Siming Xin, Jiusheng Zheng, Huai Liu, Yu Ouyang, Huoxiu Yang, Yang Zeng, Yang Zou, Xiaoming Zeng
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Medical Genomics
Subjects:
Intrahepatic cholestasis of pregnancy
Nuclear Receptor Subfamily 1 Group H Member 4
Total bile acid
Mutations
Online Access:https://doi.org/10.1186/s12920-022-01240-w

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