Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt–β-catenin target gene activation is believed to be the predominant mechanism responsible for APC...

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Bibliographic Details
Main Authors: Alexander J. Valvezan, Jian Huang, Christopher J. Lengner, Michael Pack, Peter S. Klein
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
APC
Wnt
mTOR
mTORC1
Zebrafish
Colon cancer
Polyposis
GSK-3
Online Access:http://dmm.biologists.org/content/7/1/63

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