Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran
Introduction: Dabigatran etexilate was the first direct-acting oral anticoagulant approved in the United States. The prevalence of intracranial hemorrhage after blunt head trauma in patients on dabigatran is currently unknown, complicating adequate ability to accurately compare the risks and benefit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eScholarship Publishing, University of California
2017-07-01
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| Series: | Western Journal of Emergency Medicine |
| Online Access: | https://escholarship.org/uc/item/6dw824z4 |
| _version_ | 1811253581861355520 |
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| author | James A. Chenoweth M. Austin Johnson Laura Shook Mark E. Sutter Daniel K. Nishijima James F. Holmes |
| author_facet | James A. Chenoweth M. Austin Johnson Laura Shook Mark E. Sutter Daniel K. Nishijima James F. Holmes |
| author_sort | James A. Chenoweth |
| collection | DOAJ |
| description | Introduction: Dabigatran etexilate was the first direct-acting oral anticoagulant approved in the United States. The prevalence of intracranial hemorrhage after blunt head trauma in patients on dabigatran is currently unknown, complicating adequate ability to accurately compare the risks and benefits of dabigatran to alternative anticoagulants. We aimed to determine the prevalence of intracranial hemorrhage for patients on dabigatran presenting to a Level I trauma center. Methods: This is a retrospective observational study of adult patients on dabigatran who presented to a Level I trauma center and received cranial computed tomography (CT) following blunt head trauma. Patients who met inclusion criteria underwent manual chart abstraction. Our primary outcome was intracranial hemorrhage on initial cranial CT. Results: We included a total of 33 eligible patient visits for analysis. Mean age was 74.8 years (SD 11.2, range 55–91). The most common cause of injury was ground-level fall (n = 22, 66.7%). One patient (3.0%, 95% confidence interval [CI] 0.[1–15.8%]) had intracranial hemorrhage on cranial CT. No patients (0%, 95% CI [0–8.7%]) required neurosurgical intervention. One in-hospital death occurred from infection. Conclusion: To our knowledge, this is the first study to evaluate the prevalence of intracranial hemorrhage after blunt head trauma for patients on dabigatran presenting to the emergency department, including those not admitted. The intracranial hemorrhage prevalence in our study is similar to previous reports for patients on warfarin. Further studies are needed to determine if the prevalence of intracranial hemorrhage seen in our patient population is true for a larger patient population in more diverse clinical settings. |
| first_indexed | 2024-04-12T16:53:10Z |
| format | Article |
| id | doaj.art-d68ca782adb546e0bf026a707a5ded74 |
| institution | Directory Open Access Journal |
| issn | 1936-9018 |
| language | English |
| last_indexed | 2024-04-12T16:53:10Z |
| publishDate | 2017-07-01 |
| publisher | eScholarship Publishing, University of California |
| record_format | Article |
| series | Western Journal of Emergency Medicine |
| spelling | doaj.art-d68ca782adb546e0bf026a707a5ded742022-12-22T03:24:19ZengeScholarship Publishing, University of CaliforniaWestern Journal of Emergency Medicine1936-90182017-07-0118510.5811/westjem.2017.5.33092wjem-18-794Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury DabigatranJames A. Chenoweth0M. Austin Johnson1Laura Shook2Mark E. Sutter3Daniel K. Nishijima4James F. Holmes5University of California Davis, School of Medicine, Department of Emergency Medicine, Davis, CaliforniaUniversity of California Davis, School of Medicine, Department of Emergency Medicine, Davis, CaliforniaUniversity of California Davis, School of Medicine, Davis, CaliforniaUniversity of California Davis, School of Medicine, Department of Emergency Medicine, Davis, CaliforniaUniversity of California Davis, School of Medicine, Department of Emergency Medicine, Davis, CaliforniaUniversity of California Davis, School of Medicine, Department of Emergency Medicine, Davis, CaliforniaIntroduction: Dabigatran etexilate was the first direct-acting oral anticoagulant approved in the United States. The prevalence of intracranial hemorrhage after blunt head trauma in patients on dabigatran is currently unknown, complicating adequate ability to accurately compare the risks and benefits of dabigatran to alternative anticoagulants. We aimed to determine the prevalence of intracranial hemorrhage for patients on dabigatran presenting to a Level I trauma center. Methods: This is a retrospective observational study of adult patients on dabigatran who presented to a Level I trauma center and received cranial computed tomography (CT) following blunt head trauma. Patients who met inclusion criteria underwent manual chart abstraction. Our primary outcome was intracranial hemorrhage on initial cranial CT. Results: We included a total of 33 eligible patient visits for analysis. Mean age was 74.8 years (SD 11.2, range 55–91). The most common cause of injury was ground-level fall (n = 22, 66.7%). One patient (3.0%, 95% confidence interval [CI] 0.[1–15.8%]) had intracranial hemorrhage on cranial CT. No patients (0%, 95% CI [0–8.7%]) required neurosurgical intervention. One in-hospital death occurred from infection. Conclusion: To our knowledge, this is the first study to evaluate the prevalence of intracranial hemorrhage after blunt head trauma for patients on dabigatran presenting to the emergency department, including those not admitted. The intracranial hemorrhage prevalence in our study is similar to previous reports for patients on warfarin. Further studies are needed to determine if the prevalence of intracranial hemorrhage seen in our patient population is true for a larger patient population in more diverse clinical settings.https://escholarship.org/uc/item/6dw824z4 |
| spellingShingle | James A. Chenoweth M. Austin Johnson Laura Shook Mark E. Sutter Daniel K. Nishijima James F. Holmes Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran Western Journal of Emergency Medicine |
| title | Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran |
| title_full | Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran |
| title_fullStr | Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran |
| title_full_unstemmed | Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran |
| title_short | Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran |
| title_sort | prevalence of intracranial hemorrhage after blunt head trauma in patients on pre injury dabigatran |
| url | https://escholarship.org/uc/item/6dw824z4 |
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