The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species
The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2017-0012 |
| _version_ | 1826841011891994624 |
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| author | Gutiérrez Sandra Dévora Kuri Susana Abdala Martín-Herrera Domingo |
| author_facet | Gutiérrez Sandra Dévora Kuri Susana Abdala Martín-Herrera Domingo |
| author_sort | Gutiérrez Sandra Dévora |
| collection | DOAJ |
| description | The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy’s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. Bioassay-guided fractionation of the ethyl acetate extract suggested the possible presence of pentacyclic triterpenes from oleanane and ursane series. These findings allow the conclusion that S. canariensis exerts analgesic and anti-inflammatory activities, documenting its traditional use in the treatment of pain and inflammatory diseases. |
| first_indexed | 2024-12-17T01:57:59Z |
| format | Article |
| id | doaj.art-d68f18df70684f47911d70ea72b14b40 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2025-02-16T12:52:31Z |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-d68f18df70684f47911d70ea72b14b402025-02-02T19:57:23ZengSciendoActa Pharmaceutica1846-95582017-06-0167226527310.1515/acph-2017-0012acph-2017-0012The bioguided fractionation and pharmacological activity of an endemic Salix canariensis speciesGutiérrez Sandra Dévora0Kuri Susana Abdala1Martín-Herrera Domingo2Unidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, SpainUnidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, SpainUnidad de Farmacología y Farmacognosia, Sección de Farmacia, Facultad de Ciencias de La Salud, Universidad de La Laguna, 38071, La Laguna, Tenerife, Canary Islands, SpainThe present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy’s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. Bioassay-guided fractionation of the ethyl acetate extract suggested the possible presence of pentacyclic triterpenes from oleanane and ursane series. These findings allow the conclusion that S. canariensis exerts analgesic and anti-inflammatory activities, documenting its traditional use in the treatment of pain and inflammatory diseases.https://doi.org/10.1515/acph-2017-0012salix canariensisanalgesic activityanti-inflammatory activitybioassay fractionationpentacyclic triterpenesursanesoleananes |
| spellingShingle | Gutiérrez Sandra Dévora Kuri Susana Abdala Martín-Herrera Domingo The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species Acta Pharmaceutica salix canariensis analgesic activity anti-inflammatory activity bioassay fractionation pentacyclic triterpenes ursanes oleananes |
| title | The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species |
| title_full | The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species |
| title_fullStr | The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species |
| title_full_unstemmed | The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species |
| title_short | The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species |
| title_sort | bioguided fractionation and pharmacological activity of an endemic salix canariensis species |
| topic | salix canariensis analgesic activity anti-inflammatory activity bioassay fractionation pentacyclic triterpenes ursanes oleananes |
| url | https://doi.org/10.1515/acph-2017-0012 |
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