Effect of mismatch repair genes expression in right colon cancer on pathological characteristics
Objective To investigate the defect of expression of mismatch repair genes(MMR) including MLH1, MSH2, MSH6 and PMS2 in sporadic colon cancer, and analyze the expression of MMR related to pathological change of patients with right colon cancer. Methods The data of 206 patients with colon cancer inclu...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2021-01-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1658940894572-529034933.pdf |
| _version_ | 1797648535062052864 |
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| author | YAN Wanneng, MA Haijie, SHEN Chaomin |
| author_facet | YAN Wanneng, MA Haijie, SHEN Chaomin |
| author_sort | YAN Wanneng, MA Haijie, SHEN Chaomin |
| collection | DOAJ |
| description | Objective To investigate the defect of expression of mismatch repair genes(MMR) including MLH1, MSH2, MSH6 and PMS2 in sporadic colon cancer, and analyze the expression of MMR related to pathological change of patients with right colon cancer. Methods The data of 206 patients with colon cancer including 116 cases with left colon cancer and 90 cases with right colon cancer in our hospital were collected from January 2015 to August 2020. The expression of MMR including MLH1, MSH2, MSH6 and PMS2 was detected by immunohistochemistry. The relation of defect in expression of MMR to pathological changes in colon cancer was analyzed. Results The rate of expression defect of MMR in patients with right colon cancer was higher than that in patients with left colon cancer. The expression defect of MMR was significantly related to tumor differentiation and neural invasion in patients with right colon cancer (P<0.05). Conclusions Higher rate of expression defect of MMR in patients with sporadic right colon cancer was present compared with the patients of left colon cancer. The patients of right colon cancer with expression defect of MMR have poorly pathological differentiated and are unprone to perineural invasion. |
| first_indexed | 2024-03-11T15:33:31Z |
| format | Article |
| id | doaj.art-d68f2379ffd140729219707b5798af81 |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-11T15:33:31Z |
| publishDate | 2021-01-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-d68f2379ffd140729219707b5798af812023-10-27T02:12:41ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102021-01-012601626510.16139/j.1007-9610.2021.01.013Effect of mismatch repair genes expression in right colon cancer on pathological characteristicsYAN Wanneng, MA Haijie, SHEN Chaomin0a. Department of General Surgery, Zhoushan Hospital, Zhejiang Zhoushan 316000, China;b. Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Zhejiang Zhoushan 316000, ChinaObjective To investigate the defect of expression of mismatch repair genes(MMR) including MLH1, MSH2, MSH6 and PMS2 in sporadic colon cancer, and analyze the expression of MMR related to pathological change of patients with right colon cancer. Methods The data of 206 patients with colon cancer including 116 cases with left colon cancer and 90 cases with right colon cancer in our hospital were collected from January 2015 to August 2020. The expression of MMR including MLH1, MSH2, MSH6 and PMS2 was detected by immunohistochemistry. The relation of defect in expression of MMR to pathological changes in colon cancer was analyzed. Results The rate of expression defect of MMR in patients with right colon cancer was higher than that in patients with left colon cancer. The expression defect of MMR was significantly related to tumor differentiation and neural invasion in patients with right colon cancer (P<0.05). Conclusions Higher rate of expression defect of MMR in patients with sporadic right colon cancer was present compared with the patients of left colon cancer. The patients of right colon cancer with expression defect of MMR have poorly pathological differentiated and are unprone to perineural invasion.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1658940894572-529034933.pdf|mismatch repair gene|pathology|colon cancer |
| spellingShingle | YAN Wanneng, MA Haijie, SHEN Chaomin Effect of mismatch repair genes expression in right colon cancer on pathological characteristics Waike lilun yu shijian |mismatch repair gene|pathology|colon cancer |
| title | Effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| title_full | Effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| title_fullStr | Effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| title_full_unstemmed | Effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| title_short | Effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| title_sort | effect of mismatch repair genes expression in right colon cancer on pathological characteristics |
| topic | |mismatch repair gene|pathology|colon cancer |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1658940894572-529034933.pdf |
| work_keys_str_mv | AT yanwannengmahaijieshenchaomin effectofmismatchrepairgenesexpressioninrightcoloncanceronpathologicalcharacteristics |