COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects
In the light of the lack of authorized COVID-19 vaccines adapted to the Omicron variant lineage, the administration of the first and second booster dose is recommended. It remains important to monitor the efficacy of such an approach in order to inform future preventive strategies. The present paper...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/8/1223 |
| _version_ | 1797407598437203968 |
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| author | Dorota Zarębska-Michaluk Chenlin Hu Michał Brzdęk Robert Flisiak Piotr Rzymski |
| author_facet | Dorota Zarębska-Michaluk Chenlin Hu Michał Brzdęk Robert Flisiak Piotr Rzymski |
| author_sort | Dorota Zarębska-Michaluk |
| collection | DOAJ |
| description | In the light of the lack of authorized COVID-19 vaccines adapted to the Omicron variant lineage, the administration of the first and second booster dose is recommended. It remains important to monitor the efficacy of such an approach in order to inform future preventive strategies. The present paper summarizes the research progress on the effectiveness of the first and second booster doses of COVID-19. It also discusses the potential approach in vaccination strategies that could be undertaken to maintain high levels of protection during the waves of SARS-CoV-2 infections. Although this approach can be based, with some shortcomings, on the first-generation vaccines, other vaccination strategies should be explored, including developing multiple antigen-based (multivariant-adapted) booster doses with enhanced durability of immune protection, e.g., through optimization of the half-life of generated antibodies. |
| first_indexed | 2024-03-09T03:43:52Z |
| format | Article |
| id | doaj.art-d68ff4c9e7f94ddcad6a876099ff88e7 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T03:43:52Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d68ff4c9e7f94ddcad6a876099ff88e72023-12-03T14:36:45ZengMDPI AGVaccines2076-393X2022-07-01108122310.3390/vaccines10081223COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future ProspectsDorota Zarębska-Michaluk0Chenlin Hu1Michał Brzdęk2Robert Flisiak3Piotr Rzymski4Department of Infectious Diseases, Jan Kochanowski University, 25-369 Kielce, PolandCollege of Pharmacy, University of Houston, Houston, TX 77204, USADepartment of Infectious Diseases, Jan Kochanowski University, 25-369 Kielce, PolandDepartment of Infectious Diseases and Hepatology, Medical University of Białystok, 15-540 Białystok, PolandDepartment of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznan, PolandIn the light of the lack of authorized COVID-19 vaccines adapted to the Omicron variant lineage, the administration of the first and second booster dose is recommended. It remains important to monitor the efficacy of such an approach in order to inform future preventive strategies. The present paper summarizes the research progress on the effectiveness of the first and second booster doses of COVID-19. It also discusses the potential approach in vaccination strategies that could be undertaken to maintain high levels of protection during the waves of SARS-CoV-2 infections. Although this approach can be based, with some shortcomings, on the first-generation vaccines, other vaccination strategies should be explored, including developing multiple antigen-based (multivariant-adapted) booster doses with enhanced durability of immune protection, e.g., through optimization of the half-life of generated antibodies.https://www.mdpi.com/2076-393X/10/8/1223COVID-19Omicronboostervaccine effectiveness |
| spellingShingle | Dorota Zarębska-Michaluk Chenlin Hu Michał Brzdęk Robert Flisiak Piotr Rzymski COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects Vaccines COVID-19 Omicron booster vaccine effectiveness |
| title | COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects |
| title_full | COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects |
| title_fullStr | COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects |
| title_full_unstemmed | COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects |
| title_short | COVID-19 Vaccine Booster Strategies for Omicron SARS-CoV-2 Variant: Effectiveness and Future Prospects |
| title_sort | covid 19 vaccine booster strategies for omicron sars cov 2 variant effectiveness and future prospects |
| topic | COVID-19 Omicron booster vaccine effectiveness |
| url | https://www.mdpi.com/2076-393X/10/8/1223 |
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