Delivery of nVEGFi using AAV8 for the treatment of neovascular age-related macular degeneration

Delivery of nVEGFi using AAV8 for the treatment of neovascular age-related macular degeneration

Inhibition of vascular endothelial growth factor (VEGF) is the standard therapy for neovascular age-related macular degeneration (nAMD). However, anti-VEGF agents used in the clinic require repeated injections, causing adverse effects. Gene therapy could provide sustained anti-VEGF levels after a si...

Full description

Bibliographic Details
Main Authors:	Kaiqin She, Jing Su, Qingnan Wang, Yi Liu, Xiaomei Zhong, Xiu Jin, Qinyu Zhao, Jianlu Xiao, Ruiting Li, Hongxin Deng, Fang Lu, Yang Yang, Yuquan Wei
Format:	Article
Language:	English
Published:	Elsevier 2022-03-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	neovascular age-related macular degeneration anti-vascular endothelial growth factor choroidal neovascularization VEGF trap gene therapy adeno-associated virus
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050122000031

Similar Items

Neovascular Remodeling and Subretinal Fibrosis as Biomarkers for Predicting Incomplete Response to Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration
by: Jing Wu, et al.
Published: (2022-04-01)

Comparison of ranibizumab and bevacizumab in neovascular age-related macular degeneration
by: Huseyin Serdarogullari, et al.
Published: (2014-05-01)

The Architecture of Macular Neovascularizations Predicts Treatment Responses to Anti-VEGF Therapy in Neovascular AMD
by: Henrik Faatz, et al.
Published: (2022-11-01)

Spectral domain-optical coherence tomography retinal biomarkers in choroidal neovascularization of multifocal choroiditis, myopic choroidal neovascularization, and idiopathic choroidal neovascularization
by: Rui Gao, et al.
Published: (2021-01-01)

Results of Intravitreal Anti-VEGF Injection in Choroidal Neovascularization Caused by Pathologies Other Than Age-Related Macular Degeneration
by: Mehmet Ozveren
Published: (2020-08-01)

Myopic choroidal neovascular membrane: A retrospective study
by: S Sindhu, et al.
Published: (2016-01-01)

Treatment Strategies for Anti-VEGF Resistance in Neovascular Age-Related Macular Degeneration by Targeting Arteriolar Choroidal Neovascularization
by: Yingbin Fu, et al.
Published: (2024-02-01)

Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration
by: Deokho Lee, et al.
Published: (2023-01-01)

Analysis on macular choroidal thickness of patients with myopic choroidal neovascularization
by: Yan Qiu, et al.
Published: (2015-05-01)

Conbercept for Treatment of Neovascular Age-Related Macular Degeneration and Visual Impairment due to Diabetic Macular Edema or Pathologic Myopia Choroidal Neovascularization: A Systematic Review and Meta-Analysis
by: Pengxiang Zhou, et al.
Published: (2021-10-01)

Inflammatory choroidal neovascularization in Indian eyes: Etiology, clinical features, and outcomes to anti-vascular endothelial growth factor
by: Rupak Roy, et al.
Published: (2017-01-01)

Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization
by: Sun T, et al.
Published: (2021-06-01)

Neovascular age-related macular degeneration: intraocular inflammatory cytokines in the poor responder to ranibizumab treatment
by: Pongsachareonnont P, et al.
Published: (2018-09-01)

Observation of the macular thickness after the treatment of choroidal neovascularization with pathological myopia
by: Li Yan, et al.
Published: (2018-02-01)

The formation of rats' choroidal neovascularization induced by acrolein
by: Guan-Feng Wang, et al.
Published: (2016-04-01)

Choroidal Neovascular Membranes in Retinal and Choroidal Tumors: Origins, Mechanisms, and Effects
by: Federico Di Staso, et al.
Published: (2023-01-01)

Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization
by: Shian Zhang, et al.
Published: (2022-11-01)

Dynamic changes in macrophage morphology during the progression of choroidal neovascularization in a laser-induced choroidal neovascularization mouse model
by: Nana Xu, et al.
Published: (2023-10-01)

Therapeutic effect of photodynamic therapy and intravitreal injection with ranibizumab for choroidal neovascularization of pathologic myopia
by: Cong Zhang, et al.
Published: (2014-07-01)

LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration
by: Lucia Mundo, et al.
Published: (2021-08-01)

Idiopathic choroidal neovascular membrane in a young female
by: Saad Abdullah Waheeb, et al.
Published: (2009-01-01)

Presumed Melanocytoma-Associated Choroidal Neovascular Membrane with Hemorrhage Successfully Treated with Intravitreal Aflibercept Injections
by: Austin S. Yu, et al.
Published: (2023-09-01)

Therapeutic effects of photodynamic therapy for treating choroidal neovascularization by optic coherent tomography
by: Li Song, et al.
Published: (2014-08-01)

Recent advance on anti-VEGF treatment of choroidal neovascularization secondary to pathological myopia
by: Xing-Zhao Xu, et al.
Published: (2018-09-01)

Simultaneous bilateral inflammatory choroidal neovascularization in a case of healed serpiginous-like choroiditis
by: Sood, Gitanjli, et al.
Published: (2022-05-01)

Lamellar macular hole formation following intravitreal bevacizumab injection for choroidal neovascularization by age-related macular degeneration
by: Hamidreza Torabi, et al.
Published: (2018-01-01)

Long-Term Follow-Up of Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization due to Choroidal Osteoma
by: Zenith H.Y. Wu, et al.
Published: (2012-06-01)

Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization Secondary to Endogenous Endophthalmitis
by: Shwu-Jiuan Sheu
Published: (2009-11-01)

Current and Novel Therapeutic Approaches for Treatment of Neovascular Age-Related Macular Degeneration
by: Reem H. ElSheikh, et al.
Published: (2022-11-01)

Intravitreal Ranibizumab in the Treatment of Butterfly-Shaped Pattern Dystrophy Associated with Choroidal Neovascularization: A Case Report
by: Theodoros Empeslidis, et al.
Published: (2012-02-01)

Pachychoroid neovasculopathy in extramacular choroidal neovascularization
by: Gupta MP, et al.
Published: (2016-07-01)

Predictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab
by: Lucia Gonzalez-Buendia, et al.
Published: (2017-08-01)

Recurrence of Macular Hole Retinal Detachment after Intravitreal Ranibizumab Injection for the Treatment of Choroidal Neovascularization from the Remaining Macular Hole Edge
by: Keiko Otsuka, et al.
Published: (2012-12-01)

Comparison of endostatin(endostar)and avastin's inhibition effect on mice choroidal neovascularization
by: Jing Li, et al.
Published: (2014-06-01)

Efficacy of anti-VEGF combined with compound trabeculectomy in the treatment of neovascular glaucoma
by: Cao-Yu Sun, et al.
Published: (2020-09-01)

Choroidal Osteoma and Secondary Choroidal Neovascularization Treated with Ranibizumab
by: Almila Sarıgül Sezenöz, et al.
Published: (2017-08-01)

Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization
by: Hiromasa Hirai, et al.
Published: (2024-02-01)

Clinical efficacy of intravitreal Ranibizumab in idiopathic choroid neovascularization type Ⅰand type Ⅱ
by: Yue-Ming Sun, et al.
Published: (2015-07-01)

Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography
by: Faatz H, et al.
Published: (2020-10-01)

Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography
by: Huixun Jia, et al.
Published: (2022-05-01)