Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus
Abstract Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral re...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202207249 |
| _version_ | 1797804422615531520 |
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| author | Xuan Liu Lunzhi Yuan Jijing Chen Yali Zhang Peiwen Chen Ming Zhou Jiaxuan Xie Jian Ma Jianzhong Zhang Kun Wu Qiyi Tang Quan Yuan Huachen Zhu Tong Cheng Yi Guan Gang Liu Ningshao Xia |
| author_facet | Xuan Liu Lunzhi Yuan Jijing Chen Yali Zhang Peiwen Chen Ming Zhou Jiaxuan Xie Jian Ma Jianzhong Zhang Kun Wu Qiyi Tang Quan Yuan Huachen Zhu Tong Cheng Yi Guan Gang Liu Ningshao Xia |
| author_sort | Xuan Liu |
| collection | DOAJ |
| description | Abstract Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR‐MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system. The designed CoVR‐MV interferes with the viral infection by absorbing the viruses with maximized viral spike target interface, and mediates the clearance of the virus through its inherent interaction with macrophages. Furthermore, CoVR‐MV coupled with the virus promotes a swift production and signaling of endogenous type I interferon via deregulating 7‐dehydrocholesterol reductase (DHCR7) inhibition of interferon regulatory factor 3 (IRF3) activation in macrophages. These sequential processes re‐modulate the innate immune responses to the virus, trigger spontaneous innate antiviral defenses, and rescue infected Syrian hamsters from ARDS caused by SARS‐CoV‐2 and all tested variants. |
| first_indexed | 2024-03-13T05:36:56Z |
| format | Article |
| id | doaj.art-d6954536acd14b80925f857e77e5bec4 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-13T05:36:56Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-d6954536acd14b80925f857e77e5bec42023-06-14T07:18:56ZengWileyAdvanced Science2198-38442023-06-011017n/an/a10.1002/advs.202207249Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic CoronavirusXuan Liu0Lunzhi Yuan1Jijing Chen2Yali Zhang3Peiwen Chen4Ming Zhou5Jiaxuan Xie6Jian Ma7Jianzhong Zhang8Kun Wu9Qiyi Tang10Quan Yuan11Huachen Zhu12Tong Cheng13Yi Guan14Gang Liu15Ningshao Xia16State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Emerging Infectious Diseases School of Public Health Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaDepartment of Microbiology Howard University College of Medicine Washington DC 20059 USAState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Emerging Infectious Diseases School of Public Health Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Emerging Infectious Diseases School of Public Health Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 ChinaAbstract Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR‐MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system. The designed CoVR‐MV interferes with the viral infection by absorbing the viruses with maximized viral spike target interface, and mediates the clearance of the virus through its inherent interaction with macrophages. Furthermore, CoVR‐MV coupled with the virus promotes a swift production and signaling of endogenous type I interferon via deregulating 7‐dehydrocholesterol reductase (DHCR7) inhibition of interferon regulatory factor 3 (IRF3) activation in macrophages. These sequential processes re‐modulate the innate immune responses to the virus, trigger spontaneous innate antiviral defenses, and rescue infected Syrian hamsters from ARDS caused by SARS‐CoV‐2 and all tested variants.https://doi.org/10.1002/advs.202207249ARDSbiomimetic nanocarriercell membrane vesiclesendogenous type I interferonhighly pathogenic coronavirusimbalanced innate immune responses |
| spellingShingle | Xuan Liu Lunzhi Yuan Jijing Chen Yali Zhang Peiwen Chen Ming Zhou Jiaxuan Xie Jian Ma Jianzhong Zhang Kun Wu Qiyi Tang Quan Yuan Huachen Zhu Tong Cheng Yi Guan Gang Liu Ningshao Xia Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus Advanced Science ARDS biomimetic nanocarrier cell membrane vesicles endogenous type I interferon highly pathogenic coronavirus imbalanced innate immune responses |
| title | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
| title_full | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
| title_fullStr | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
| title_full_unstemmed | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
| title_short | Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus |
| title_sort | antiviral nanobiologic therapy remodulates innate immune responses to highly pathogenic coronavirus |
| topic | ARDS biomimetic nanocarrier cell membrane vesicles endogenous type I interferon highly pathogenic coronavirus imbalanced innate immune responses |
| url | https://doi.org/10.1002/advs.202207249 |
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