| Summary: | Eighteen compounds, including fourteen flavonoids (<b>1</b>–<b>14</b>), one steroid (<b>15</b>), two fatty acids (<b>16</b>,<b>17</b>), and one nitrogen-containing compound (<b>18</b>), were isolated from the methanol extract of the whole <i>Blumea lacera</i> plant collected in Thailand. Compounds <b>1</b>–<b>11</b> and <b>15</b>–<b>17</b> exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin (<b>2</b>) and cirsilineol (<b>7</b>) had particularly strong TRAIL resistance-overcoming activity, where the IC<sub>50</sub> values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 μM and 5.9 μM, respectively.
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