Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i>
Eighteen compounds, including fourteen flavonoids (<b>1</b>–<b>14</b>), one steroid (<b>15</b>), two fatty acids (<b>16</b>,<b>17</b>), and one nitrogen-containing compound (<b>18</b>), were isolated from the methanol extract of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/1/264 |
| _version_ | 1797440363340759040 |
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| author | Teruhisa Manome Yasumasa Hara Masami Ishibashi |
| author_facet | Teruhisa Manome Yasumasa Hara Masami Ishibashi |
| author_sort | Teruhisa Manome |
| collection | DOAJ |
| description | Eighteen compounds, including fourteen flavonoids (<b>1</b>–<b>14</b>), one steroid (<b>15</b>), two fatty acids (<b>16</b>,<b>17</b>), and one nitrogen-containing compound (<b>18</b>), were isolated from the methanol extract of the whole <i>Blumea lacera</i> plant collected in Thailand. Compounds <b>1</b>–<b>11</b> and <b>15</b>–<b>17</b> exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin (<b>2</b>) and cirsilineol (<b>7</b>) had particularly strong TRAIL resistance-overcoming activity, where the IC<sub>50</sub> values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 μM and 5.9 μM, respectively. |
| first_indexed | 2024-03-09T12:07:05Z |
| format | Article |
| id | doaj.art-d6963e8ef1c54e48ab267559ec2db62a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:07:05Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d6963e8ef1c54e48ab267559ec2db62a2023-11-30T22:57:37ZengMDPI AGMolecules1420-30492022-12-0128126410.3390/molecules28010264Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i>Teruhisa Manome0Yasumasa Hara1Masami Ishibashi2Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, JapanEighteen compounds, including fourteen flavonoids (<b>1</b>–<b>14</b>), one steroid (<b>15</b>), two fatty acids (<b>16</b>,<b>17</b>), and one nitrogen-containing compound (<b>18</b>), were isolated from the methanol extract of the whole <i>Blumea lacera</i> plant collected in Thailand. Compounds <b>1</b>–<b>11</b> and <b>15</b>–<b>17</b> exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin (<b>2</b>) and cirsilineol (<b>7</b>) had particularly strong TRAIL resistance-overcoming activity, where the IC<sub>50</sub> values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 μM and 5.9 μM, respectively.https://www.mdpi.com/1420-3049/28/1/264flavonoids<i>Blumea lacera</i>TRAIL resistanceThai plant |
| spellingShingle | Teruhisa Manome Yasumasa Hara Masami Ishibashi Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> Molecules flavonoids <i>Blumea lacera</i> TRAIL resistance Thai plant |
| title | Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> |
| title_full | Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> |
| title_fullStr | Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> |
| title_full_unstemmed | Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> |
| title_short | Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from <i>Blumea lacera</i> |
| title_sort | isolation of various flavonoids with trail resistance overcoming activity from i blumea lacera i |
| topic | flavonoids <i>Blumea lacera</i> TRAIL resistance Thai plant |
| url | https://www.mdpi.com/1420-3049/28/1/264 |
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