An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women
Uncomplicated recurrent urinary tract infections (rUTIs) in women are associated with episodic bothersome symptoms and have a significant impact on the mental and physical quality of life. Treatment with antibiotics (short- and long-term dosing) results in acute and chronic side effects and costs an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/3/359 |
| _version_ | 1797609669076713472 |
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| author | J. Curtis Nickel R. Christopher Doiron |
| author_facet | J. Curtis Nickel R. Christopher Doiron |
| author_sort | J. Curtis Nickel |
| collection | DOAJ |
| description | Uncomplicated recurrent urinary tract infections (rUTIs) in women are associated with episodic bothersome symptoms and have a significant impact on the mental and physical quality of life. Treatment with antibiotics (short- and long-term dosing) results in acute and chronic side effects and costs and promotes general antibiotic resistance. Improved nonantibiotic management of rUTI in women represents a true, unmet medical need. MV140 is a novel sublingual mucosal-based bacterial vaccine developed for the prevention of rUTI in women. Based on observational, prospective, and randomized placebo-controlled studies, MV140 has been shown to safely prevent (or reduce the risk of) UTIs, reduce antibiotic use, overall management costs, and patient burden while improving the overall quality of life in women suffering from rUTIs. |
| first_indexed | 2024-03-11T06:03:37Z |
| format | Article |
| id | doaj.art-d69762162bc74bd785545318bce3d114 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T06:03:37Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-d69762162bc74bd785545318bce3d1142023-11-17T13:08:52ZengMDPI AGPathogens2076-08172023-02-0112335910.3390/pathogens12030359An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in WomenJ. Curtis Nickel0R. Christopher Doiron1Department of Urology, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Urology, Queen’s University, Kingston, ON K7L 3N6, CanadaUncomplicated recurrent urinary tract infections (rUTIs) in women are associated with episodic bothersome symptoms and have a significant impact on the mental and physical quality of life. Treatment with antibiotics (short- and long-term dosing) results in acute and chronic side effects and costs and promotes general antibiotic resistance. Improved nonantibiotic management of rUTI in women represents a true, unmet medical need. MV140 is a novel sublingual mucosal-based bacterial vaccine developed for the prevention of rUTI in women. Based on observational, prospective, and randomized placebo-controlled studies, MV140 has been shown to safely prevent (or reduce the risk of) UTIs, reduce antibiotic use, overall management costs, and patient burden while improving the overall quality of life in women suffering from rUTIs.https://www.mdpi.com/2076-0817/12/3/359urinary tract infectionsvaccinerecurrent urinary tract infectionswomen’s health |
| spellingShingle | J. Curtis Nickel R. Christopher Doiron An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women Pathogens urinary tract infections vaccine recurrent urinary tract infections women’s health |
| title | An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women |
| title_full | An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women |
| title_fullStr | An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women |
| title_full_unstemmed | An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women |
| title_short | An Effective Sublingual Vaccine, MV140, Safely Reduces Risk of Recurrent Urinary Tract Infection in Women |
| title_sort | effective sublingual vaccine mv140 safely reduces risk of recurrent urinary tract infection in women |
| topic | urinary tract infections vaccine recurrent urinary tract infections women’s health |
| url | https://www.mdpi.com/2076-0817/12/3/359 |
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