Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

<h4>Background</h4>The Conditional by Inversion (COIN) method for engineering conditional alleles relies on an invertible optimized gene trap-like element, the COIN module, for imparting conditionality. The COIN module contains an optimized 3' splice site-polyadenylation signal pair...

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Bibliographic Details
Main Authors: Nikolaos Mandalos, Marannia Saridaki, Jessica Lea Harper, Anastasia Kotsoni, Peter Yang, Aris N Economides, Eumorphia Remboutsika
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029233/?tool=EBI

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