Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study
Background and AimAlthough the treatment effect and availability of therapeutic options for advanced hepatocellular carcinoma (HCC) are limited, the downstaging strategy may improve patient prognosis. This study aimed to investigate the potential of combination therapy as a downstaging strategy for...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.650394/full |
_version_ | 1818621558266003456 |
---|---|
author | Yun Huang Zeyu Zhang Weijun Liao Kuan Hu Zhiming Wang |
author_facet | Yun Huang Zeyu Zhang Weijun Liao Kuan Hu Zhiming Wang |
author_sort | Yun Huang |
collection | DOAJ |
description | Background and AimAlthough the treatment effect and availability of therapeutic options for advanced hepatocellular carcinoma (HCC) are limited, the downstaging strategy may improve patient prognosis. This study aimed to investigate the potential of combination therapy as a downstaging strategy for treating advanced HCC with portal vein tumor thrombus (PVTT).MethodsThis retrospective case series included patients having advanced HCC with PVTT, who received the combination therapy of sorafenib, camrelizumab, transcatheter arterial chemoembolization (TACE), and stereotactic body radiation therapy (SBRT) from January 2019 to December 2019 in Xiangya Hospital, Central South University. The downstaging rate, treatment responses, progression-free survival (PFS), overall survival (OS), disease control rate, and toxicities were evaluated.ResultsOf the 13 patients, HCC downstaging was achieved in 4 (33.3%) patients who later received hepatectomy. The overall response rate was 41.7%, and the disease control rate was 50.0%. The median PFS time was 15.7 months, with a 1-year PFS rate of 58.3%, whereas the median OS was not reached after 1 year (1-year OS, 83.3%). No severe adverse events or grade 3–4 adverse effect was observed in 12 of the 13 enrolled patients; therapy had to be discontinued in only one patient due to adverse events, who was excluded from the study. The most common adverse effect was fever (n = 4, 33.3%), followed by skin reaction (n = 3, 25%).ConclusionA combination therapy comprising sorafenib, camrelizumab, TACE, and SBRT is an effective downstaging strategy for advanced HCC with PVTT and is associated with few adverse events. |
first_indexed | 2024-12-16T18:11:11Z |
format | Article |
id | doaj.art-d69812dfa8264285ac28aa5509a32240 |
institution | Directory Open Access Journal |
issn | 2234-943X |
language | English |
last_indexed | 2024-12-16T18:11:11Z |
publishDate | 2021-08-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Oncology |
spelling | doaj.art-d69812dfa8264285ac28aa5509a322402022-12-21T22:21:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.650394650394Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series StudyYun HuangZeyu ZhangWeijun LiaoKuan HuZhiming WangBackground and AimAlthough the treatment effect and availability of therapeutic options for advanced hepatocellular carcinoma (HCC) are limited, the downstaging strategy may improve patient prognosis. This study aimed to investigate the potential of combination therapy as a downstaging strategy for treating advanced HCC with portal vein tumor thrombus (PVTT).MethodsThis retrospective case series included patients having advanced HCC with PVTT, who received the combination therapy of sorafenib, camrelizumab, transcatheter arterial chemoembolization (TACE), and stereotactic body radiation therapy (SBRT) from January 2019 to December 2019 in Xiangya Hospital, Central South University. The downstaging rate, treatment responses, progression-free survival (PFS), overall survival (OS), disease control rate, and toxicities were evaluated.ResultsOf the 13 patients, HCC downstaging was achieved in 4 (33.3%) patients who later received hepatectomy. The overall response rate was 41.7%, and the disease control rate was 50.0%. The median PFS time was 15.7 months, with a 1-year PFS rate of 58.3%, whereas the median OS was not reached after 1 year (1-year OS, 83.3%). No severe adverse events or grade 3–4 adverse effect was observed in 12 of the 13 enrolled patients; therapy had to be discontinued in only one patient due to adverse events, who was excluded from the study. The most common adverse effect was fever (n = 4, 33.3%), followed by skin reaction (n = 3, 25%).ConclusionA combination therapy comprising sorafenib, camrelizumab, TACE, and SBRT is an effective downstaging strategy for advanced HCC with PVTT and is associated with few adverse events.https://www.frontiersin.org/articles/10.3389/fonc.2021.650394/fullcamrelizumabdownstaging strategyhepatocellular carcinomasorafenibstereotactic body radiation therapytranscatheter arterial chemoembolization |
spellingShingle | Yun Huang Zeyu Zhang Weijun Liao Kuan Hu Zhiming Wang Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study Frontiers in Oncology camrelizumab downstaging strategy hepatocellular carcinoma sorafenib stereotactic body radiation therapy transcatheter arterial chemoembolization |
title | Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study |
title_full | Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study |
title_fullStr | Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study |
title_full_unstemmed | Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study |
title_short | Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study |
title_sort | combination of sorafenib camrelizumab transcatheter arterial chemoembolization and stereotactic body radiation therapy as a novel downstaging strategy in advanced hepatocellular carcinoma with portal vein tumor thrombus a case series study |
topic | camrelizumab downstaging strategy hepatocellular carcinoma sorafenib stereotactic body radiation therapy transcatheter arterial chemoembolization |
url | https://www.frontiersin.org/articles/10.3389/fonc.2021.650394/full |
work_keys_str_mv | AT yunhuang combinationofsorafenibcamrelizumabtranscatheterarterialchemoembolizationandstereotacticbodyradiationtherapyasanoveldownstagingstrategyinadvancedhepatocellularcarcinomawithportalveintumorthrombusacaseseriesstudy AT zeyuzhang combinationofsorafenibcamrelizumabtranscatheterarterialchemoembolizationandstereotacticbodyradiationtherapyasanoveldownstagingstrategyinadvancedhepatocellularcarcinomawithportalveintumorthrombusacaseseriesstudy AT weijunliao combinationofsorafenibcamrelizumabtranscatheterarterialchemoembolizationandstereotacticbodyradiationtherapyasanoveldownstagingstrategyinadvancedhepatocellularcarcinomawithportalveintumorthrombusacaseseriesstudy AT kuanhu combinationofsorafenibcamrelizumabtranscatheterarterialchemoembolizationandstereotacticbodyradiationtherapyasanoveldownstagingstrategyinadvancedhepatocellularcarcinomawithportalveintumorthrombusacaseseriesstudy AT zhimingwang combinationofsorafenibcamrelizumabtranscatheterarterialchemoembolizationandstereotacticbodyradiationtherapyasanoveldownstagingstrategyinadvancedhepatocellularcarcinomawithportalveintumorthrombusacaseseriesstudy |