Photo‐Chemical Stimulation of Neurons with Organic Semiconductors
Abstract Recent advances in light‐responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution‐processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical react...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202300473 |
| _version_ | 1827771046967640064 |
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| author | Achilleas Savva Adel Hama Gabriel Herrera‐López Tony Schmidt Ludovico Migliaccio Nadia Steiner Malak Kawan Hubert Fiumelli Pierre J. Magistretti Iain McCulloch Derya Baran Nicola Gasparini Rainer Schindl Eric D. Głowacki Sahika Inal |
| author_facet | Achilleas Savva Adel Hama Gabriel Herrera‐López Tony Schmidt Ludovico Migliaccio Nadia Steiner Malak Kawan Hubert Fiumelli Pierre J. Magistretti Iain McCulloch Derya Baran Nicola Gasparini Rainer Schindl Eric D. Głowacki Sahika Inal |
| author_sort | Achilleas Savva |
| collection | DOAJ |
| description | Abstract Recent advances in light‐responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution‐processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p‐type semiconducting polymer PDCBT and the n‐type semiconducting small molecule ITIC (a non‐fullerene acceptor) are coated on glass supports, forming a p–n junction with high photosensitivity. Patch clamp measurements show that low‐intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p–n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo‐capacitive, photo‐thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low‐intensity photo‐chemical intervention with neuron electrophysiology pave the way for developing wireless light‐based therapy based on emerging organic semiconductors. |
| first_indexed | 2024-03-11T12:48:08Z |
| format | Article |
| id | doaj.art-d698642ea81d4007aa9272fa61f01d9f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-11T12:48:08Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-d698642ea81d4007aa9272fa61f01d9f2023-11-04T08:56:52ZengWileyAdvanced Science2198-38442023-11-011031n/an/a10.1002/advs.202300473Photo‐Chemical Stimulation of Neurons with Organic SemiconductorsAchilleas Savva0Adel Hama1Gabriel Herrera‐López2Tony Schmidt3Ludovico Migliaccio4Nadia Steiner5Malak Kawan6Hubert Fiumelli7Pierre J. Magistretti8Iain McCulloch9Derya Baran10Nicola Gasparini11Rainer Schindl12Eric D. Głowacki13Sahika Inal14Biological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaGottfried Schatz Research Center Chair of Biophysics Medical University of Graz Neue Stiftingtalstraße 6 Graz 8010 AustriaBioelectronics Materials and Devices Laboratory Central European Institute of Technology Brno University of Technology Purkyňova 123 Brno 61200 Czech RepublicBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaPhysical Science and Engineering (PSE) KAUST Solar Center (KSC) King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaPhysical Science and Engineering (PSE) KAUST Solar Center (KSC) King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaDepartment of Chemistry and Centre for Processable Electronics Imperial College London London W12 0BZ UKGottfried Schatz Research Center Chair of Biophysics Medical University of Graz Neue Stiftingtalstraße 6 Graz 8010 AustriaBioelectronics Materials and Devices Laboratory Central European Institute of Technology Brno University of Technology Purkyňova 123 Brno 61200 Czech RepublicBiological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Saudi ArabiaAbstract Recent advances in light‐responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution‐processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p‐type semiconducting polymer PDCBT and the n‐type semiconducting small molecule ITIC (a non‐fullerene acceptor) are coated on glass supports, forming a p–n junction with high photosensitivity. Patch clamp measurements show that low‐intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p–n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo‐capacitive, photo‐thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low‐intensity photo‐chemical intervention with neuron electrophysiology pave the way for developing wireless light‐based therapy based on emerging organic semiconductors.https://doi.org/10.1002/advs.202300473non‐fullerene acceptorsorganic bioelectronicsphoto‐stimulation |
| spellingShingle | Achilleas Savva Adel Hama Gabriel Herrera‐López Tony Schmidt Ludovico Migliaccio Nadia Steiner Malak Kawan Hubert Fiumelli Pierre J. Magistretti Iain McCulloch Derya Baran Nicola Gasparini Rainer Schindl Eric D. Głowacki Sahika Inal Photo‐Chemical Stimulation of Neurons with Organic Semiconductors Advanced Science non‐fullerene acceptors organic bioelectronics photo‐stimulation |
| title | Photo‐Chemical Stimulation of Neurons with Organic Semiconductors |
| title_full | Photo‐Chemical Stimulation of Neurons with Organic Semiconductors |
| title_fullStr | Photo‐Chemical Stimulation of Neurons with Organic Semiconductors |
| title_full_unstemmed | Photo‐Chemical Stimulation of Neurons with Organic Semiconductors |
| title_short | Photo‐Chemical Stimulation of Neurons with Organic Semiconductors |
| title_sort | photo chemical stimulation of neurons with organic semiconductors |
| topic | non‐fullerene acceptors organic bioelectronics photo‐stimulation |
| url | https://doi.org/10.1002/advs.202300473 |
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