Durotaxis and negative durotaxis: where should cells go?
Abstract Durotaxis and negative durotaxis are processes in which cell migration is directed by extracellular stiffness. Durotaxis is the tendency of cells to migrate toward stiffer areas, while negative durotaxis occurs when cells migrate toward regions with lower stiffness. The mechanisms of both p...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05554-y |
| _version_ | 1827709060046127104 |
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| author | Congcong Ji Yuxing Huang |
| author_facet | Congcong Ji Yuxing Huang |
| author_sort | Congcong Ji |
| collection | DOAJ |
| description | Abstract Durotaxis and negative durotaxis are processes in which cell migration is directed by extracellular stiffness. Durotaxis is the tendency of cells to migrate toward stiffer areas, while negative durotaxis occurs when cells migrate toward regions with lower stiffness. The mechanisms of both processes are not yet fully understood. Additionally, the connection between durotaxis and negative durotaxis remains unclear. In this review, we compare the mechanisms underlying durotaxis and negative durotaxis, summarize the basic principles of both, discuss the possible reasons why some cell types exhibit durotaxis while others exhibit negative durotaxis, propose mechanisms of switching between these processes, and emphasize the challenges in the investigation of durotaxis and negative durotaxis. |
| first_indexed | 2024-03-10T17:14:34Z |
| format | Article |
| id | doaj.art-d69970a0c0f84de9973ef813f56f71ce |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:14:34Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-d69970a0c0f84de9973ef813f56f71ce2023-11-20T10:33:34ZengNature PortfolioCommunications Biology2399-36422023-11-01611710.1038/s42003-023-05554-yDurotaxis and negative durotaxis: where should cells go?Congcong Ji0Yuxing Huang1Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & InstituteCenter for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking UniversityAbstract Durotaxis and negative durotaxis are processes in which cell migration is directed by extracellular stiffness. Durotaxis is the tendency of cells to migrate toward stiffer areas, while negative durotaxis occurs when cells migrate toward regions with lower stiffness. The mechanisms of both processes are not yet fully understood. Additionally, the connection between durotaxis and negative durotaxis remains unclear. In this review, we compare the mechanisms underlying durotaxis and negative durotaxis, summarize the basic principles of both, discuss the possible reasons why some cell types exhibit durotaxis while others exhibit negative durotaxis, propose mechanisms of switching between these processes, and emphasize the challenges in the investigation of durotaxis and negative durotaxis.https://doi.org/10.1038/s42003-023-05554-y |
| spellingShingle | Congcong Ji Yuxing Huang Durotaxis and negative durotaxis: where should cells go? Communications Biology |
| title | Durotaxis and negative durotaxis: where should cells go? |
| title_full | Durotaxis and negative durotaxis: where should cells go? |
| title_fullStr | Durotaxis and negative durotaxis: where should cells go? |
| title_full_unstemmed | Durotaxis and negative durotaxis: where should cells go? |
| title_short | Durotaxis and negative durotaxis: where should cells go? |
| title_sort | durotaxis and negative durotaxis where should cells go |
| url | https://doi.org/10.1038/s42003-023-05554-y |
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