Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches
Respirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and thera...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/12/2706 |
| _version_ | 1797379674809040896 |
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| author | Aditi Negi Shubham Nimbkar Jeyan Arthur Moses |
| author_facet | Aditi Negi Shubham Nimbkar Jeyan Arthur Moses |
| author_sort | Aditi Negi |
| collection | DOAJ |
| description | Respirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and therapeutic efficacy of dry powder formulations. Furthermore, advances in top-down and bottom-up techniques in particle preparation, highlighting their roles in tailoring particle properties and optimizing therapeutic outcomes, are also presented. Practices adopted for particle engineering during the past 100 years indicate a significant transition in research and commercial interest in the strategies used, with several innovative concepts coming into play in the past decade. Accordingly, this article highlights futuristic particle engineering approaches such as electrospraying, inkjet printing, thin film freeze drying, and supercritical processes, including their prospects and associated challenges. With such technologies, it is possible to reshape inhaled therapeutic ingredient delivery, optimizing therapeutic benefits and improving the quality of life for patients with respiratory diseases and beyond. |
| first_indexed | 2024-03-08T20:27:28Z |
| format | Article |
| id | doaj.art-d69a9ab1bc394733acfb8a2219a1468d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T20:27:28Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d69a9ab1bc394733acfb8a2219a1468d2023-12-22T14:32:04ZengMDPI AGPharmaceutics1999-49232023-11-011512270610.3390/pharmaceutics15122706Engineering Inhalable Therapeutic Particles: Conventional and Emerging ApproachesAditi Negi0Shubham Nimbkar1Jeyan Arthur Moses2Computational Modeling and Nanoscale Processing Unit, National Institute of Food Technology, Entrepreneurship and Management—Thanjavur, Ministry of Food Processing Industries, Government of India, Thanjavur 613005, Tamil Nadu, IndiaFood Processing Business Incubation Centre, National Institute of Food Technology, Entrepreneurship and Management—Thanjavur, Ministry of Food Processing Industries, Government of India, Thanjavur 613005, Tamil Nadu, IndiaComputational Modeling and Nanoscale Processing Unit, National Institute of Food Technology, Entrepreneurship and Management—Thanjavur, Ministry of Food Processing Industries, Government of India, Thanjavur 613005, Tamil Nadu, IndiaRespirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and therapeutic efficacy of dry powder formulations. Furthermore, advances in top-down and bottom-up techniques in particle preparation, highlighting their roles in tailoring particle properties and optimizing therapeutic outcomes, are also presented. Practices adopted for particle engineering during the past 100 years indicate a significant transition in research and commercial interest in the strategies used, with several innovative concepts coming into play in the past decade. Accordingly, this article highlights futuristic particle engineering approaches such as electrospraying, inkjet printing, thin film freeze drying, and supercritical processes, including their prospects and associated challenges. With such technologies, it is possible to reshape inhaled therapeutic ingredient delivery, optimizing therapeutic benefits and improving the quality of life for patients with respiratory diseases and beyond.https://www.mdpi.com/1999-4923/15/12/2706dry powder inhalerpulmonary deliveryaerosolizationparticle engineeringtherapeutic efficiency |
| spellingShingle | Aditi Negi Shubham Nimbkar Jeyan Arthur Moses Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches Pharmaceutics dry powder inhaler pulmonary delivery aerosolization particle engineering therapeutic efficiency |
| title | Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches |
| title_full | Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches |
| title_fullStr | Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches |
| title_full_unstemmed | Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches |
| title_short | Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches |
| title_sort | engineering inhalable therapeutic particles conventional and emerging approaches |
| topic | dry powder inhaler pulmonary delivery aerosolization particle engineering therapeutic efficiency |
| url | https://www.mdpi.com/1999-4923/15/12/2706 |
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