Non-Episodic Angioedema Associated with Eosinophilia after COVID-19
ntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease aft...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2022-12-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/3671 |
| _version_ | 1797956761452281856 |
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| author | Taku Harada Shintaro Kosaka Mori Nakai |
| author_facet | Taku Harada Shintaro Kosaka Mori Nakai |
| author_sort | Taku Harada |
| collection | DOAJ |
| description | ntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease after coronavirus disease 2019 (COVID-19), the occurrence of NEAE has not been previously reported.
Case description: A 29-year-old Japanese woman, with a history of allergic rhinitis and atopic dermatitis, sought a medical consultation for persisting oedema of the extremities, which developed about 2 weeks after she contracted COVID-19. Physical examination revealed symmetrical non-pitting oedema with peripheral predominance. Laboratory examination revealed a blood eosinophil count of 7536/µl. The patient was diagnosed with NEAE and a 7-day course of prednisolone (15 mg/day) was initiated, with rapid improvement in the oedema and no recurrence on follow-up.
Discussion: The exact aetiology of NEAE is unknown, but it may develop after infection or drug exposure. Eosinophilic disease after COVID-19 infection has been reported and, therefore, eosinophilic angioedema should be considered in the differential diagnosis of non-pitting oedema of the extremities after a COVID-19 infection. Early diagnosis of NEAE is important as rapid improvement can be achieved with low-dose steroid treatment.
Conclusion: NEAE can develop after COVID-19 and should be considered in the differential diagnosis of non-pitting oedema of the extremities. |
| first_indexed | 2024-04-10T23:53:55Z |
| format | Article |
| id | doaj.art-d69b9f9e3e0f4a5f962f5a63efe642ef |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-10T23:53:55Z |
| publishDate | 2022-12-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-d69b9f9e3e0f4a5f962f5a63efe642ef2023-01-10T15:02:27ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942022-12-0110.12890/2022_0036713206Non-Episodic Angioedema Associated with Eosinophilia after COVID-19Taku Harada0Shintaro Kosaka1Mori Nakai2Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan; Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, JapanDepartment of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, JapanDepartment of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japanntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease after coronavirus disease 2019 (COVID-19), the occurrence of NEAE has not been previously reported. Case description: A 29-year-old Japanese woman, with a history of allergic rhinitis and atopic dermatitis, sought a medical consultation for persisting oedema of the extremities, which developed about 2 weeks after she contracted COVID-19. Physical examination revealed symmetrical non-pitting oedema with peripheral predominance. Laboratory examination revealed a blood eosinophil count of 7536/µl. The patient was diagnosed with NEAE and a 7-day course of prednisolone (15 mg/day) was initiated, with rapid improvement in the oedema and no recurrence on follow-up. Discussion: The exact aetiology of NEAE is unknown, but it may develop after infection or drug exposure. Eosinophilic disease after COVID-19 infection has been reported and, therefore, eosinophilic angioedema should be considered in the differential diagnosis of non-pitting oedema of the extremities after a COVID-19 infection. Early diagnosis of NEAE is important as rapid improvement can be achieved with low-dose steroid treatment. Conclusion: NEAE can develop after COVID-19 and should be considered in the differential diagnosis of non-pitting oedema of the extremities.https://www.ejcrim.com/index.php/EJCRIM/article/view/3671covid-19non-episodic angioedema with eosinophilia non-pitting oedema |
| spellingShingle | Taku Harada Shintaro Kosaka Mori Nakai Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 European Journal of Case Reports in Internal Medicine covid-19 non-episodic angioedema with eosinophilia non-pitting oedema |
| title | Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 |
| title_full | Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 |
| title_fullStr | Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 |
| title_full_unstemmed | Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 |
| title_short | Non-Episodic Angioedema Associated with Eosinophilia after COVID-19 |
| title_sort | non episodic angioedema associated with eosinophilia after covid 19 |
| topic | covid-19 non-episodic angioedema with eosinophilia non-pitting oedema |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/3671 |
| work_keys_str_mv | AT takuharada nonepisodicangioedemaassociatedwitheosinophiliaaftercovid19 AT shintarokosaka nonepisodicangioedemaassociatedwitheosinophiliaaftercovid19 AT morinakai nonepisodicangioedemaassociatedwitheosinophiliaaftercovid19 |