Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature
Abstract Background The infrapatellar fat pad (IFP) may have bilateral influence on knee osteoarthritis (KOA). IFP evaluation may be a key contributor to the diagnostic and clinical management of KOA. Few studies have evaluated KOA-related IFP alteration with radiomics. We investigated radiomic sign...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06433-7 |
| _version_ | 1827957072229040128 |
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| author | Qin Ye Dong He Xiaonan Ding Yajie Wang Yuguo Wei Jing Liu |
| author_facet | Qin Ye Dong He Xiaonan Ding Yajie Wang Yuguo Wei Jing Liu |
| author_sort | Qin Ye |
| collection | DOAJ |
| description | Abstract Background The infrapatellar fat pad (IFP) may have bilateral influence on knee osteoarthritis (KOA). IFP evaluation may be a key contributor to the diagnostic and clinical management of KOA. Few studies have evaluated KOA-related IFP alteration with radiomics. We investigated radiomic signature for the assessment of IFP for KOA progression in older adults. Methods A total of 164 knees were enrolled and grouped based on Kellgren-Lawrence (KL) scoring. MRI-based radiomic features were calculated from IFP segmentation. The radiomic signature was developed using the most predictive subset of features and the machine-learning algorithm with minimum relative standard deviation. KOA severity and structure abnormality were assessed using a modified whole-organ magnetic resonance imaging score (WORMS). The performance of the radiomic signature was evaluated and the correlation with WORMS assessments was analyzed. Results The area under the curve of the radiomic signature for diagnosing KOA was 0.83 and 0.78 in the training and test datasets, respectively. Rad-scores were 0.41 and 2.01 for the training dataset in the groups with and without KOA (P < 0.001) and 0.63 and 2.31 for the test dataset (P = 0.005), respectively. WORMS significantly and positively correlated with rad-scores. Conclusions The radiomic signature may be a reliable biomarker to detect IFP abnormality of KOA. Radiomic alterations in IFP were associated with severity and knee structural abnormalities of KOA in older adults. |
| first_indexed | 2024-04-09T15:14:24Z |
| format | Article |
| id | doaj.art-d69beb7e5e9f449ca4d5963e20594692 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T15:14:24Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-d69beb7e5e9f449ca4d5963e205946922023-04-30T11:02:47ZengBMCBMC Musculoskeletal Disorders1471-24742023-04-012411910.1186/s12891-023-06433-7Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signatureQin Ye0Dong He1Xiaonan Ding2Yajie Wang3Yuguo Wei4Jing Liu5Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCenter for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCenter for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCenter for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegePrecision Health Institution, General Electric HealthcareCenter for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Background The infrapatellar fat pad (IFP) may have bilateral influence on knee osteoarthritis (KOA). IFP evaluation may be a key contributor to the diagnostic and clinical management of KOA. Few studies have evaluated KOA-related IFP alteration with radiomics. We investigated radiomic signature for the assessment of IFP for KOA progression in older adults. Methods A total of 164 knees were enrolled and grouped based on Kellgren-Lawrence (KL) scoring. MRI-based radiomic features were calculated from IFP segmentation. The radiomic signature was developed using the most predictive subset of features and the machine-learning algorithm with minimum relative standard deviation. KOA severity and structure abnormality were assessed using a modified whole-organ magnetic resonance imaging score (WORMS). The performance of the radiomic signature was evaluated and the correlation with WORMS assessments was analyzed. Results The area under the curve of the radiomic signature for diagnosing KOA was 0.83 and 0.78 in the training and test datasets, respectively. Rad-scores were 0.41 and 2.01 for the training dataset in the groups with and without KOA (P < 0.001) and 0.63 and 2.31 for the test dataset (P = 0.005), respectively. WORMS significantly and positively correlated with rad-scores. Conclusions The radiomic signature may be a reliable biomarker to detect IFP abnormality of KOA. Radiomic alterations in IFP were associated with severity and knee structural abnormalities of KOA in older adults.https://doi.org/10.1186/s12891-023-06433-7Knee osteoarthritisRadiomicsInfrapatellar fat padMagnetic resonance imaging |
| spellingShingle | Qin Ye Dong He Xiaonan Ding Yajie Wang Yuguo Wei Jing Liu Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature BMC Musculoskeletal Disorders Knee osteoarthritis Radiomics Infrapatellar fat pad Magnetic resonance imaging |
| title | Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature |
| title_full | Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature |
| title_fullStr | Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature |
| title_full_unstemmed | Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature |
| title_short | Quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis: MRI-based radiomic signature |
| title_sort | quantitative evaluation of the infrapatellar fat pad in knee osteoarthritis mri based radiomic signature |
| topic | Knee osteoarthritis Radiomics Infrapatellar fat pad Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12891-023-06433-7 |
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