Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α

Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α

The potential role of brown and beige adipose tissue against obesity has been recognized. Browning, or beiging of white adipose tissue (WAT) is associated with the remodeling of adipocytes and the improvement of their metabolic and secretory functions. Here, palmitoylethanolamide (PEA) restore the p...

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Bibliographic Details
Main Authors: Chiara Annunziata, Claudio Pirozzi, Adriano Lama, Martina Senzacqua, Federica Comella, Antonella Bordin, Anna Monnolo, Alessandra Pelagalli, Maria Carmela Ferrante, Maria Pina Mollica, Angelo Iossa, Elena De Falco, Giuseppina Mattace Raso, Saverio Cinti, Antonio Giordano, Rosaria Meli
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
brown and white adipose tissue
beige adipocytes
adipocyte remodeling
peroxisome proliferator-activated receptor-a
leptin signaling
human adipose stromal cells
Online Access:https://www.mdpi.com/1999-4923/14/2/338

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