Lung Organoids for Hazard Assessment of Nanomaterials
Lung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/24/15666 |
| _version_ | 1797457292851937280 |
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| author | Miriam T. Kastlmeier Eva M. Guenther Tobias Stoeger Carola Voss |
| author_facet | Miriam T. Kastlmeier Eva M. Guenther Tobias Stoeger Carola Voss |
| author_sort | Miriam T. Kastlmeier |
| collection | DOAJ |
| description | Lung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells from either human or mouse. In this perspective we will highlight advantages and disadvantages of traditional culture systems frequently used for testing nanomaterials and compare them to lung epithelial organoids. We also discuss the differences between tissue and iPSC-derived organoids and give an outlook in which direction the whole field could possibly go with these versatile tools. |
| first_indexed | 2024-03-09T16:20:07Z |
| format | Article |
| id | doaj.art-d69c4b250c744951be67fbd91a4ef829 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:20:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d69c4b250c744951be67fbd91a4ef8292023-11-24T15:25:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241566610.3390/ijms232415666Lung Organoids for Hazard Assessment of NanomaterialsMiriam T. Kastlmeier0Eva M. Guenther1Tobias Stoeger2Carola Voss3Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, GermanyInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, GermanyInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, GermanyInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, GermanyLung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells from either human or mouse. In this perspective we will highlight advantages and disadvantages of traditional culture systems frequently used for testing nanomaterials and compare them to lung epithelial organoids. We also discuss the differences between tissue and iPSC-derived organoids and give an outlook in which direction the whole field could possibly go with these versatile tools.https://www.mdpi.com/1422-0067/23/24/15666nanomaterialpulmonary particle exposureorganoids3D in vitro modelspluripotent stem cellsrespiratory toxicity |
| spellingShingle | Miriam T. Kastlmeier Eva M. Guenther Tobias Stoeger Carola Voss Lung Organoids for Hazard Assessment of Nanomaterials International Journal of Molecular Sciences nanomaterial pulmonary particle exposure organoids 3D in vitro models pluripotent stem cells respiratory toxicity |
| title | Lung Organoids for Hazard Assessment of Nanomaterials |
| title_full | Lung Organoids for Hazard Assessment of Nanomaterials |
| title_fullStr | Lung Organoids for Hazard Assessment of Nanomaterials |
| title_full_unstemmed | Lung Organoids for Hazard Assessment of Nanomaterials |
| title_short | Lung Organoids for Hazard Assessment of Nanomaterials |
| title_sort | lung organoids for hazard assessment of nanomaterials |
| topic | nanomaterial pulmonary particle exposure organoids 3D in vitro models pluripotent stem cells respiratory toxicity |
| url | https://www.mdpi.com/1422-0067/23/24/15666 |
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