Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patien...
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MDPI AG
2020-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/6/337 |
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| author | Shennie Tan Chien Tai Hong Jia-Hung Chen Lung Chan Wen-Chou Chi Chia-Feng Yen Hua-Fang Liao Tsan-Hon Liou Dean Wu |
| author_facet | Shennie Tan Chien Tai Hong Jia-Hung Chen Lung Chan Wen-Chou Chi Chia-Feng Yen Hua-Fang Liao Tsan-Hon Liou Dean Wu |
| author_sort | Shennie Tan |
| collection | DOAJ |
| description | In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patients with moderate-to-advanced PD. Moderate and advanced PD patients with and without dementia were identified from the Taiwan Data Bank of Persons with Disability. Hand fine motor capacities, namely pen holding, buttoning, and knotting, were assessed with the World Health Organization Disability Assessment Schedule 2.0. Statistical analyses were performed on Statistical Analysis System (SAS) and a <i>p</i> value of <0.05 was considered significant. In total, 3440 patients with PD were enrolled, of which 612 had dementia, exhibiting significant disability in all three tasks. After adjustments for age, sex, and PD severity, pen holding and knotting were significantly associated with PD dementia. The presence of any disability in either task was not only sensitive to the presence of dementia but also associated with cognitive disability in moderate and advanced PD patients without dementia. In conclusion, hand fine motor skill disability was associated with cognitive disability in patients with moderate-to-advanced PD. These simple hand fine motor skills may thus be applicable in screening tests for the early identification of cognitive dysfunction in patients with moderate-to-advanced PD. |
| first_indexed | 2024-03-10T19:26:14Z |
| format | Article |
| id | doaj.art-d69e1c151f074cfb932a3bd2ceefe77a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T19:26:14Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d69e1c151f074cfb932a3bd2ceefe77a2023-11-20T02:33:13ZengMDPI AGBrain Sciences2076-34252020-06-0110633710.3390/brainsci10060337Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s DiseaseShennie Tan0Chien Tai Hong1Jia-Hung Chen2Lung Chan3Wen-Chou Chi4Chia-Feng Yen5Hua-Fang Liao6Tsan-Hon Liou7Dean Wu8Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanTaiwan Society of International Classification of Functioning, Disability and Health, TSICF, New Taipei City 23561, TaiwanTaiwan Society of International Classification of Functioning, Disability and Health, TSICF, New Taipei City 23561, TaiwanTaiwan Society of International Classification of Functioning, Disability and Health, TSICF, New Taipei City 23561, TaiwanTaiwan Society of International Classification of Functioning, Disability and Health, TSICF, New Taipei City 23561, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanIn older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patients with moderate-to-advanced PD. Moderate and advanced PD patients with and without dementia were identified from the Taiwan Data Bank of Persons with Disability. Hand fine motor capacities, namely pen holding, buttoning, and knotting, were assessed with the World Health Organization Disability Assessment Schedule 2.0. Statistical analyses were performed on Statistical Analysis System (SAS) and a <i>p</i> value of <0.05 was considered significant. In total, 3440 patients with PD were enrolled, of which 612 had dementia, exhibiting significant disability in all three tasks. After adjustments for age, sex, and PD severity, pen holding and knotting were significantly associated with PD dementia. The presence of any disability in either task was not only sensitive to the presence of dementia but also associated with cognitive disability in moderate and advanced PD patients without dementia. In conclusion, hand fine motor skill disability was associated with cognitive disability in patients with moderate-to-advanced PD. These simple hand fine motor skills may thus be applicable in screening tests for the early identification of cognitive dysfunction in patients with moderate-to-advanced PD.https://www.mdpi.com/2076-3425/10/6/337Parkinson’s diseasedementiacognitionfine movement |
| spellingShingle | Shennie Tan Chien Tai Hong Jia-Hung Chen Lung Chan Wen-Chou Chi Chia-Feng Yen Hua-Fang Liao Tsan-Hon Liou Dean Wu Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease Brain Sciences Parkinson’s disease dementia cognition fine movement |
| title | Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease |
| title_full | Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease |
| title_fullStr | Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease |
| title_full_unstemmed | Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease |
| title_short | Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease |
| title_sort | hand fine motor skill disability correlates with cognition in patients with moderate to advanced parkinson s disease |
| topic | Parkinson’s disease dementia cognition fine movement |
| url | https://www.mdpi.com/2076-3425/10/6/337 |
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