“Jianbing” styling multifunctional electrospinning composite membranes for wound healing
Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.943695/full |
| _version_ | 1798015881508290560 |
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| author | Hanqiang Zhao Youguang Xu Saisai Wang Pan Li Ting Wang Fang Zhang Juan Li Yapei Zhang Jinlong Ma Jinlong Ma Jinlong Ma Weifen Zhang Weifen Zhang Weifen Zhang |
| author_facet | Hanqiang Zhao Youguang Xu Saisai Wang Pan Li Ting Wang Fang Zhang Juan Li Yapei Zhang Jinlong Ma Jinlong Ma Jinlong Ma Weifen Zhang Weifen Zhang Weifen Zhang |
| author_sort | Hanqiang Zhao |
| collection | DOAJ |
| description | Wound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. In vitro, the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit Pseudomonas aeruginosa. Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. In vivo, it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid. |
| first_indexed | 2024-04-11T15:41:52Z |
| format | Article |
| id | doaj.art-d6a04763f3ac4736b88ef598f26221a5 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T15:41:52Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d6a04763f3ac4736b88ef598f26221a52022-12-22T04:15:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.943695943695“Jianbing” styling multifunctional electrospinning composite membranes for wound healingHanqiang Zhao0Youguang Xu1Saisai Wang2Pan Li3Ting Wang4Fang Zhang5Juan Li6Yapei Zhang7Jinlong Ma8Jinlong Ma9Jinlong Ma10Weifen Zhang11Weifen Zhang12Weifen Zhang13School of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Pharmacy, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, United StatesSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaCollaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, Shandong, ChinaShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Weifang Medical University, Weifang, Shandong, ChinaCollaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, Shandong, ChinaShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, Shandong, ChinaWound infection and excessive exudate can affect the process of wound healing. However, the disadvantage of the anti-microbial wound dressings is that the biological fluids are ineffectively removed. Inspired by making “Chinese Jianbing”, a composite wound nano-dressing was developed consisting of a hydrophilic outer layer (chitosan&polyvinyl alcohol: CTS-PVA) and a hydrophobic inner layer (propolis&polycaprolactone: PRO-PCL) by combining casting and electrospinning methods for effective antibacterial and unidirectional removing excess biofluids. In vitro, the composite wound nano-dressing of PRO-PCL and CTS-PVA (PPCP) could strongly inhibit Pseudomonas aeruginosa. Furthermore, PPCP wound dressing had excellent antioxidant properties and blood coagulation index for effective hemostatic. Importantly, it had a preferable water absorption for removing excess biofluid. In vivo, it had anti-inflammatory properties and promoted collagen Ⅰ preparation, which realized 80% wound healing on day 7. In short, the PPCP wound dressing provides a new direction and option for antibacterial and removes excess biofluid.https://www.frontiersin.org/articles/10.3389/fbioe.2022.943695/fullwound dressingcomposite membranesantibacterialremove excess biofluidantioxidant |
| spellingShingle | Hanqiang Zhao Youguang Xu Saisai Wang Pan Li Ting Wang Fang Zhang Juan Li Yapei Zhang Jinlong Ma Jinlong Ma Jinlong Ma Weifen Zhang Weifen Zhang Weifen Zhang “Jianbing” styling multifunctional electrospinning composite membranes for wound healing Frontiers in Bioengineering and Biotechnology wound dressing composite membranes antibacterial remove excess biofluid antioxidant |
| title | “Jianbing” styling multifunctional electrospinning composite membranes for wound healing |
| title_full | “Jianbing” styling multifunctional electrospinning composite membranes for wound healing |
| title_fullStr | “Jianbing” styling multifunctional electrospinning composite membranes for wound healing |
| title_full_unstemmed | “Jianbing” styling multifunctional electrospinning composite membranes for wound healing |
| title_short | “Jianbing” styling multifunctional electrospinning composite membranes for wound healing |
| title_sort | jianbing styling multifunctional electrospinning composite membranes for wound healing |
| topic | wound dressing composite membranes antibacterial remove excess biofluid antioxidant |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.943695/full |
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