Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India
Background/Aim: Dementia has become a public health problem due to its association with biological risk factors; obesity, diabetes, hypertension and hypercholesterolaemia. Most of these risk factors, appear to be associated with dementia as well as with risk of coronary artery diseases (CADs) and st...
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Format: | Article |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2023-01-01
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Series: | Scripta Medica |
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Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292302149S.pdf |
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author | Singh Ram B. Wilczynska Agnieszka Fedacko Jan Horiuchi Rie Takahashi Toru Fatima Ghizal Ismail Manal Magomedova Aminat Moshiri Arsha Moshiri Mahmood |
author_facet | Singh Ram B. Wilczynska Agnieszka Fedacko Jan Horiuchi Rie Takahashi Toru Fatima Ghizal Ismail Manal Magomedova Aminat Moshiri Arsha Moshiri Mahmood |
author_sort | Singh Ram B. |
collection | DOAJ |
description | Background/Aim: Dementia has become a public health problem due to its association with biological risk factors; obesity, diabetes, hypertension and hypercholesterolaemia. Most of these risk factors, appear to be associated with dementia as well as with risk of coronary artery diseases (CADs) and stroke. This study aimed to find out the association of biological risk factors with cognitive impairment and dementia. Methods: Cross-sectional survey in a hospital was performed. After written informed consent and approval from hospital ethic committee, all subjects (n = 2002) above 25 years of age (1016 males and 986 females) were randomly selected and recruited from urban population of Moradabad, North India. Clinical data and risk factors were recorded with the help of case record form and validated questionnaires. Assessment of cognitive decline and dementia was made by Singh's memory function rating scale and biological risk factors by physical examination, sphygmomanometer and electrocardiography. The association of biological risk factors with dementia was calculated by multivariate logistic regression analysis after adjustment of age and sex. Results: Obesity, diabetes, hypertension, CAD and hypercholesterolemia were highly prevalent independent risk factors among patients with dementia. Multivariate logistic regression analysis showed that regardless of age and body mass index, diabetes mellitus and CAD were highly significant (p < 0.001) risk factors of dementia. Hypertension and family history of dementia were weakly but significantly(p < 0.05) associated with dementia. Conclusion: It is possible that increased frequency of obesity, diabetes, hypertension and CAD may increase the risk of dementia in an ageing population. Prevention and control of these biological risk factors may cause decline in the risk of dementia. |
first_indexed | 2024-03-13T01:28:33Z |
format | Article |
id | doaj.art-d6a21e217e5146c6af3bcb82c4cf12c0 |
institution | Directory Open Access Journal |
issn | 2490-3329 2303-7954 |
language | English |
last_indexed | 2024-03-13T01:28:33Z |
publishDate | 2023-01-01 |
publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
record_format | Article |
series | Scripta Medica |
spelling | doaj.art-d6a21e217e5146c6af3bcb82c4cf12c02023-07-04T10:50:16ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542023-01-015421491552490-33292302149SAssociation of cardiovascular and metabolic diseases with risk of dementia in the urban population of North IndiaSingh Ram B.0Wilczynska Agnieszka1Fedacko Jan2Horiuchi Rie3Takahashi Toru4Fatima Ghizal5Ismail Manal6Magomedova Aminat7Moshiri Arsha8Moshiri Mahmood9Halberg Hospital and Research Institute, Moradabad, IndiaAmerican Center for Psychiatry and Neurology, Dubai, UAEPJ Safaric University, Kosice, SlovakiaMukogawa Women's University, Nishinomiya City, JapanFukuoka University, Graduate School of Human Environmental Medicine, Fukuoka, JapanEra University, Era Medical College, Lucknow, IndiaUniversity of Central Lancashire, College of Science and Technology, School of Natural Sciences, Preston, England, UKLomosonov Moscow State University, Moscow, RussiaInternational College of Cardiology, Richmond Hill, ON, CanadaInternational College of Cardiology, Richmond Hill, ON, CanadaBackground/Aim: Dementia has become a public health problem due to its association with biological risk factors; obesity, diabetes, hypertension and hypercholesterolaemia. Most of these risk factors, appear to be associated with dementia as well as with risk of coronary artery diseases (CADs) and stroke. This study aimed to find out the association of biological risk factors with cognitive impairment and dementia. Methods: Cross-sectional survey in a hospital was performed. After written informed consent and approval from hospital ethic committee, all subjects (n = 2002) above 25 years of age (1016 males and 986 females) were randomly selected and recruited from urban population of Moradabad, North India. Clinical data and risk factors were recorded with the help of case record form and validated questionnaires. Assessment of cognitive decline and dementia was made by Singh's memory function rating scale and biological risk factors by physical examination, sphygmomanometer and electrocardiography. The association of biological risk factors with dementia was calculated by multivariate logistic regression analysis after adjustment of age and sex. Results: Obesity, diabetes, hypertension, CAD and hypercholesterolemia were highly prevalent independent risk factors among patients with dementia. Multivariate logistic regression analysis showed that regardless of age and body mass index, diabetes mellitus and CAD were highly significant (p < 0.001) risk factors of dementia. Hypertension and family history of dementia were weakly but significantly(p < 0.05) associated with dementia. Conclusion: It is possible that increased frequency of obesity, diabetes, hypertension and CAD may increase the risk of dementia in an ageing population. Prevention and control of these biological risk factors may cause decline in the risk of dementia.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292302149S.pdfwestern dietsedentary behaviourmasticationcardiovascular diseases |
spellingShingle | Singh Ram B. Wilczynska Agnieszka Fedacko Jan Horiuchi Rie Takahashi Toru Fatima Ghizal Ismail Manal Magomedova Aminat Moshiri Arsha Moshiri Mahmood Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India Scripta Medica western diet sedentary behaviour mastication cardiovascular diseases |
title | Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India |
title_full | Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India |
title_fullStr | Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India |
title_full_unstemmed | Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India |
title_short | Association of cardiovascular and metabolic diseases with risk of dementia in the urban population of North India |
title_sort | association of cardiovascular and metabolic diseases with risk of dementia in the urban population of north india |
topic | western diet sedentary behaviour mastication cardiovascular diseases |
url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2023/2490-33292302149S.pdf |
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