Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography
Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation. Transdermal drug delivery overcomes the aforementioned d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2689 |
| _version_ | 1797455747319070720 |
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| author | Yingying Zhou Xiazi Huang Jiyu Li Ting Zhu Weiran Pang Larry Chow Liming Nie Lei Sun Puxiang Lai |
| author_facet | Yingying Zhou Xiazi Huang Jiyu Li Ting Zhu Weiran Pang Larry Chow Liming Nie Lei Sun Puxiang Lai |
| author_sort | Yingying Zhou |
| collection | DOAJ |
| description | Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation. Transdermal drug delivery overcomes the aforementioned defects, and the microneedles (MNs) array is one of the most promising transdermal drug delivery platforms. Timely, precise, and non-invasive monitoring and evaluation of the effects of MNs in transdermal administration is significant to the research of drug efficiency response to specific diseases. In this sense, photoacoustic computed tomography (PACT), which provides wavelength-selective and deep-penetrating optical contrast, could be a promising imaging tool for in situ evaluation of the treatment effects. In this work, we propose the use of PACT to non-invasively assess the effects of real-time drug delivery in glioma tumors through transdermal administration with degradable indocyanine green-loaded hyaluronic acid MNs (ICG-HA-MNs). The outcome is systematically and quantitatively compared with that via intravenous injection. It is found that the photoacoustic signals of ICG in the tumor site express a faster elevation and shorter duration time in the intravenous injection group; by contrast, the photoacoustic signals demonstrate a lower intensity but prolonged duration time in the MNs group. The observed phenomenon indicates faster response but shorter drug duration for intravenous injection, which is in contrast with the lower loading but prolonged performance for transdermal drug delivery with MNs. These results exhibit good consistency with the earlier, common-sense findings reported from other aspects, confirming that PACT can serve as a potential imaging tool to precisely, non-invasively, and quickly evaluate in situ drug delivery effects and provide constructive guidance for the design and fabrication of microneedles. |
| first_indexed | 2024-03-09T15:58:46Z |
| format | Article |
| id | doaj.art-d6a2e86e925443239e5a5df168d2b018 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d6a2e86e925443239e5a5df168d2b0182023-11-24T17:20:19ZengMDPI AGPharmaceutics1999-49232022-12-011412268910.3390/pharmaceutics14122689Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic TomographyYingying Zhou0Xiazi Huang1Jiyu Li2Ting Zhu3Weiran Pang4Larry Chow5Liming Nie6Lei Sun7Puxiang Lai8Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Applied Biology & Chemistry Technology, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaResearch Center of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, ChinaIntravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation. Transdermal drug delivery overcomes the aforementioned defects, and the microneedles (MNs) array is one of the most promising transdermal drug delivery platforms. Timely, precise, and non-invasive monitoring and evaluation of the effects of MNs in transdermal administration is significant to the research of drug efficiency response to specific diseases. In this sense, photoacoustic computed tomography (PACT), which provides wavelength-selective and deep-penetrating optical contrast, could be a promising imaging tool for in situ evaluation of the treatment effects. In this work, we propose the use of PACT to non-invasively assess the effects of real-time drug delivery in glioma tumors through transdermal administration with degradable indocyanine green-loaded hyaluronic acid MNs (ICG-HA-MNs). The outcome is systematically and quantitatively compared with that via intravenous injection. It is found that the photoacoustic signals of ICG in the tumor site express a faster elevation and shorter duration time in the intravenous injection group; by contrast, the photoacoustic signals demonstrate a lower intensity but prolonged duration time in the MNs group. The observed phenomenon indicates faster response but shorter drug duration for intravenous injection, which is in contrast with the lower loading but prolonged performance for transdermal drug delivery with MNs. These results exhibit good consistency with the earlier, common-sense findings reported from other aspects, confirming that PACT can serve as a potential imaging tool to precisely, non-invasively, and quickly evaluate in situ drug delivery effects and provide constructive guidance for the design and fabrication of microneedles.https://www.mdpi.com/1999-4923/14/12/2689photoacoustic computed tomographytransdermal drug deliverymicroneedles arrayinjection |
| spellingShingle | Yingying Zhou Xiazi Huang Jiyu Li Ting Zhu Weiran Pang Larry Chow Liming Nie Lei Sun Puxiang Lai Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography Pharmaceutics photoacoustic computed tomography transdermal drug delivery microneedles array injection |
| title | Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography |
| title_full | Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography |
| title_fullStr | Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography |
| title_full_unstemmed | Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography |
| title_short | Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography |
| title_sort | small animal in situ drug delivery effects via transdermal microneedles array versus intravenous injection a pilot observation based on photoacoustic tomography |
| topic | photoacoustic computed tomography transdermal drug delivery microneedles array injection |
| url | https://www.mdpi.com/1999-4923/14/12/2689 |
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