Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies
Abstract Background The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adip...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07299-x |
| _version_ | 1828791476041023488 |
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| author | Junyu Zhao Jing Wen Shengnan Wang Jinming Yao Lin Liao Jianjun Dong |
| author_facet | Junyu Zhao Jing Wen Shengnan Wang Jinming Yao Lin Liao Jianjun Dong |
| author_sort | Junyu Zhao |
| collection | DOAJ |
| description | Abstract Background The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. Methods Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was then performed through a fixed or random-effects model to calculate I values for heterogeneity analysis. Results Twenty-nine articles were finally included for analysis. The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I2 = 98%, P = 0.008] and the ratio of TNF-α immunoreactivity in tissues [odds ratios (OR) =6.36, 95% CI: 1.92 to 21.05, I2 = 66%, P = 0.002] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD = 1.04, 95% CI: 0.40 to 1.67, I2 = 96%, P = 0.001). There is no significant difference of the ratio of IL-6 immunoreactivity in tissues between carcinoma and control (OR = 1.23, 95% CI: 0.62 to 2.43, I2 = 86%, P = 0.55). The ratio of leptin immunoreactivity in tissues is significantly associated with the risk of thyroid carcinoma (OR = 12.21, 95% CI: 3.36 to 44.40, I2 = 85%, P < 0.00001). However, after analyzing the expression level of serum adiponectin in three studies, no significant difference is found between thyroid carcinoma and the control (P = 0.81). Conclusions Adipokines (TNF-α, IL-6 and leptin) show a strong relationship between elevated concentrations (in serum and/or tissue) and thyroid carcinoma. However, the association between adiponectin and thyroid carcinoma needs further research. |
| first_indexed | 2024-12-12T02:51:31Z |
| format | Article |
| id | doaj.art-d6a39af43396467aac004fd20b81395c |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-12T02:51:31Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d6a39af43396467aac004fd20b81395c2022-12-22T00:40:53ZengBMCBMC Cancer1471-24072020-08-0120111310.1186/s12885-020-07299-xAssociation between adipokines and thyroid carcinoma: a meta-analysis of case-control studiesJunyu Zhao0Jing Wen1Shengnan Wang2Jinming Yao3Lin Liao4Jianjun Dong5Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese MedicineDepartment of Endocrinology and Metabology, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalDepartment of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan HospitalDepartment of Endocrinology and Metabology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong UniversityAbstract Background The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. Methods Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was then performed through a fixed or random-effects model to calculate I values for heterogeneity analysis. Results Twenty-nine articles were finally included for analysis. The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I2 = 98%, P = 0.008] and the ratio of TNF-α immunoreactivity in tissues [odds ratios (OR) =6.36, 95% CI: 1.92 to 21.05, I2 = 66%, P = 0.002] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid carcinoma is higher than that in control (SMD = 1.04, 95% CI: 0.40 to 1.67, I2 = 96%, P = 0.001). There is no significant difference of the ratio of IL-6 immunoreactivity in tissues between carcinoma and control (OR = 1.23, 95% CI: 0.62 to 2.43, I2 = 86%, P = 0.55). The ratio of leptin immunoreactivity in tissues is significantly associated with the risk of thyroid carcinoma (OR = 12.21, 95% CI: 3.36 to 44.40, I2 = 85%, P < 0.00001). However, after analyzing the expression level of serum adiponectin in three studies, no significant difference is found between thyroid carcinoma and the control (P = 0.81). Conclusions Adipokines (TNF-α, IL-6 and leptin) show a strong relationship between elevated concentrations (in serum and/or tissue) and thyroid carcinoma. However, the association between adiponectin and thyroid carcinoma needs further research.http://link.springer.com/article/10.1186/s12885-020-07299-xThyroid carcinomaAdipokinesTNF-αIL-6LeptinMeta-analysis |
| spellingShingle | Junyu Zhao Jing Wen Shengnan Wang Jinming Yao Lin Liao Jianjun Dong Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies BMC Cancer Thyroid carcinoma Adipokines TNF-α IL-6 Leptin Meta-analysis |
| title | Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies |
| title_full | Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies |
| title_fullStr | Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies |
| title_full_unstemmed | Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies |
| title_short | Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies |
| title_sort | association between adipokines and thyroid carcinoma a meta analysis of case control studies |
| topic | Thyroid carcinoma Adipokines TNF-α IL-6 Leptin Meta-analysis |
| url | http://link.springer.com/article/10.1186/s12885-020-07299-x |
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