Dabigatran etexilate - A novel oral anticoagulant for bleeding complications
Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2015-09-01
|
| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-20&slc_lang=en&sid=1 |
| _version_ | 1818306053126750208 |
|---|---|
| author | Himabindu Reddy Chakka Gopinath Mohamed Saleem Thattakudian Sheikuduman |
| author_facet | Himabindu Reddy Chakka Gopinath Mohamed Saleem Thattakudian Sheikuduman |
| author_sort | Himabindu Reddy |
| collection | DOAJ |
| description | Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. Dabigatran etexilate is an orally effective anti-thrombin drug, several animal and human trials were conformed the efficacy of this drug in reduction of major bleeding in related to acute coronary syndrome, knee replacement surgery and venous thromboembolism conditions. The therapeutic use of this drug also shows limited side effects to select the dabigatran as promising therapeutic agent in bleeding complications. |
| first_indexed | 2024-12-13T06:36:22Z |
| format | Article |
| id | doaj.art-d6a47e0eccc94f63abceaba91d275159 |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-13T06:36:22Z |
| publishDate | 2015-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-d6a47e0eccc94f63abceaba91d2751592022-12-21T23:56:30ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942015-09-0113110Dabigatran etexilate - A novel oral anticoagulant for bleeding complicationsHimabindu Reddy0Chakka Gopinath1Mohamed Saleem Thattakudian Sheikuduman2 Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India Department of Pharmacology and Pharmacy Practice, Annamacharya College of Pharmacy, Rajampet, India Thromboembolic disease is a common cause of morbidity and mortality. Thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. Anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. Dabigatran etexilate is an orally effective anti-thrombin drug, several animal and human trials were conformed the efficacy of this drug in reduction of major bleeding in related to acute coronary syndrome, knee replacement surgery and venous thromboembolism conditions. The therapeutic use of this drug also shows limited side effects to select the dabigatran as promising therapeutic agent in bleeding complications.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-20&slc_lang=en&sid=1Anticoagulation dabigatran Thromboembolic disease thrombin inhibition |
| spellingShingle | Himabindu Reddy Chakka Gopinath Mohamed Saleem Thattakudian Sheikuduman Dabigatran etexilate - A novel oral anticoagulant for bleeding complications Pharmaceutical and Biomedical Research Anticoagulation dabigatran Thromboembolic disease thrombin inhibition |
| title | Dabigatran etexilate - A novel oral anticoagulant for bleeding complications |
| title_full | Dabigatran etexilate - A novel oral anticoagulant for bleeding complications |
| title_fullStr | Dabigatran etexilate - A novel oral anticoagulant for bleeding complications |
| title_full_unstemmed | Dabigatran etexilate - A novel oral anticoagulant for bleeding complications |
| title_short | Dabigatran etexilate - A novel oral anticoagulant for bleeding complications |
| title_sort | dabigatran etexilate a novel oral anticoagulant for bleeding complications |
| topic | Anticoagulation dabigatran Thromboembolic disease thrombin inhibition |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-20&slc_lang=en&sid=1 |
| work_keys_str_mv | AT himabindureddy dabigatranetexilateanoveloralanticoagulantforbleedingcomplications AT chakkagopinath dabigatranetexilateanoveloralanticoagulantforbleedingcomplications AT mohamedsaleemthattakudiansheikuduman dabigatranetexilateanoveloralanticoagulantforbleedingcomplications |