Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin
Background and Objectives: Dandelion (Taraxacum sp) is among the valuable medicinal plants; its antifungal properties have been proven. However, no study investigated the antifungal effects of Taraxacum perigynium, a native species of Iran. This study compared the effects of ethanolic and aqueous ex...
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2021-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
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| Online Access: | http://journal.muq.ac.ir/article-1-3016-en.html |
| _version_ | 1818434957386711040 |
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| author | Alireza Akhzari Zahra Nasrollai Movasaghe Yazdanpanah Ahmad Abolhasani Hoda Abolhasani |
| author_facet | Alireza Akhzari Zahra Nasrollai Movasaghe Yazdanpanah Ahmad Abolhasani Hoda Abolhasani |
| author_sort | Alireza Akhzari |
| collection | DOAJ |
| description | Background and Objectives: Dandelion (Taraxacum sp) is among the valuable medicinal plants; its antifungal properties have been proven. However, no study investigated the antifungal effects of Taraxacum perigynium, a native species of Iran. This study compared the effects of ethanolic and aqueous extracts of dandelion root on three species of Candida albicans, Aspergillus niger, and Trichophyton rubrum with fluconazole and nystatin, as antifungal drugs.
Methods In this study, ethanolic and aqueous extracts of Iranian dandelion root were prepared. To evaluate the antifungal effects of dandelion root extracts and two standard antifungal drugs, fluconazole and nystatin, the Minimum Inhibitory Concentration (MIC) was recorded by evaluating the growth rate of fungi using broth microdilution method, according to the light absorption obtained from the spectrophotometer. Eventually, the obtained data were analyzed by Analysis of Variance (ANOVA).
Results The present research results suggested that dandelion root ethanolic extract presented inhibitory properties on all 3 studied fungal strains. The obtained data indicated the highest inhibitory effects on Candida albicans with a minimum inhibitory concentration of 150 µg/mL. The aqueous extract of dandelion root provided no antifungal effect. Fluconazole and nystatin presented a greater antifungal effect than the ethanolic extract of dandelion root in all 3 fungal strains.
Conclusion Due to various therapeutic effects and no significant adverse effects, dandelion root can be used as an adjunct therapy in the treatment and control of various fungal infections. Therefore, it is suggested to identify and isolate the compounds in Taraxacum peregrinium and other species of dandelion native to Iran. It is also recommended to evaluate the identified components concerning antifungal properties. |
| first_indexed | 2024-12-14T16:45:14Z |
| format | Article |
| id | doaj.art-d6a4cceeb5994a30a66d7784e4f1233b |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-14T16:45:14Z |
| publishDate | 2021-03-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-d6a4cceeb5994a30a66d7784e4f1233b2022-12-21T22:54:12ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752021-03-011512027Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and NystatinAlireza Akhzari0Zahra Nasrollai1Movasaghe Yazdanpanah2Ahmad Abolhasani3Hoda Abolhasani4 Student Research Committee, Faculty of Paramedical, Qom university of Medical Sciences, Qom, Iran. Spiritual Health Research Center, Faculty of Health and Religion, Qom University of Medical Sciences, Qom, Iran. Cellular and Molecular Research Center, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran. Department of Chemical Engineering, Faculty of Technology and Engineering, Qom Uuniversity, Qom, Iran. Department of Pharmacology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran. Background and Objectives: Dandelion (Taraxacum sp) is among the valuable medicinal plants; its antifungal properties have been proven. However, no study investigated the antifungal effects of Taraxacum perigynium, a native species of Iran. This study compared the effects of ethanolic and aqueous extracts of dandelion root on three species of Candida albicans, Aspergillus niger, and Trichophyton rubrum with fluconazole and nystatin, as antifungal drugs. Methods In this study, ethanolic and aqueous extracts of Iranian dandelion root were prepared. To evaluate the antifungal effects of dandelion root extracts and two standard antifungal drugs, fluconazole and nystatin, the Minimum Inhibitory Concentration (MIC) was recorded by evaluating the growth rate of fungi using broth microdilution method, according to the light absorption obtained from the spectrophotometer. Eventually, the obtained data were analyzed by Analysis of Variance (ANOVA). Results The present research results suggested that dandelion root ethanolic extract presented inhibitory properties on all 3 studied fungal strains. The obtained data indicated the highest inhibitory effects on Candida albicans with a minimum inhibitory concentration of 150 µg/mL. The aqueous extract of dandelion root provided no antifungal effect. Fluconazole and nystatin presented a greater antifungal effect than the ethanolic extract of dandelion root in all 3 fungal strains. Conclusion Due to various therapeutic effects and no significant adverse effects, dandelion root can be used as an adjunct therapy in the treatment and control of various fungal infections. Therefore, it is suggested to identify and isolate the compounds in Taraxacum peregrinium and other species of dandelion native to Iran. It is also recommended to evaluate the identified components concerning antifungal properties.http://journal.muq.ac.ir/article-1-3016-en.htmltaraxacumherbal medicinetaraxacum peregriniumantifungal agentscandida albicans |
| spellingShingle | Alireza Akhzari Zahra Nasrollai Movasaghe Yazdanpanah Ahmad Abolhasani Hoda Abolhasani Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum taraxacum herbal medicine taraxacum peregrinium antifungal agents candida albicans |
| title | Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin |
| title_full | Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin |
| title_fullStr | Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin |
| title_full_unstemmed | Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin |
| title_short | Antifungal Evaluation of Aqueous and Ethanolic Extract of Iranian Dandelion Root, Compared With Fluconazole and Nystatin |
| title_sort | antifungal evaluation of aqueous and ethanolic extract of iranian dandelion root compared with fluconazole and nystatin |
| topic | taraxacum herbal medicine taraxacum peregrinium antifungal agents candida albicans |
| url | http://journal.muq.ac.ir/article-1-3016-en.html |
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