Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria
Recently in Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase. This paper therefore evaluates the bioactive compounds of three herbal drinks and their concomitant effects on selected hepatic biomarkers in albino Wister...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2020-01-01
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| Series: | Journal of Applied Sciences and Environmental Management |
| Subjects: | |
| Online Access: | https://www.ajol.info/index.php/jasem/article/view/192515 |
| _version_ | 1797197490585337856 |
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| author | A.B. Ojekale O. Lawal M.O. Lasisi C.A. Bamgbose F.A. Dosu |
| author_facet | A.B. Ojekale O. Lawal M.O. Lasisi C.A. Bamgbose F.A. Dosu |
| author_sort | A.B. Ojekale |
| collection | DOAJ |
| description |
Recently in Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase. This paper therefore evaluates the bioactive compounds of three herbal drinks and their concomitant effects on selected hepatic biomarkers in albino Wister rats in Lagos, Nigeria using standard methods. A total of 31 bioactive compounds were positively identified in the three bitter drinks analyzed, Out of which are: Yoyo (5-Hydroxymethylfurfural (6.8%), Coumaran (1.7%), Octamethyl cyclotetrasiloxane ( 4.5%), Squalene(3.2%) - 2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one(1.7%),3,3-Dimethyl-2butanol(1.1%),2-Hydroxy-2- cyclopenten-1-one (0.7%)). Swedish (Camphor (82.9%), Cinnamic acid (0.2%)). Living (5-Hydroxymethylfurfural 57.4%), Coumaran (1.6%), 3, 4-dihydroxy-3-cyclobutene-1, 2-dione (0.3%). The three bitters had no common bioactive compound between
them. Five common bioactive compounds were detected present in both Living and Yoyo bitters. Only 11 (about 35%) of the 31 compounds identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. The three bitters orally administered to rats from data gathered were not dangerous to the liver over the 40day period of the experiment.
Keywords: Yoyo, Swedish, living, hepatic biomarkers
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| first_indexed | 2024-04-24T06:44:48Z |
| format | Article |
| id | doaj.art-d6a59a8fcbd34d57a9ec4c3c7a35853f |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T06:44:48Z |
| publishDate | 2020-01-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-d6a59a8fcbd34d57a9ec4c3c7a35853f2024-04-22T19:47:03ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992020-01-012312Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, NigeriaA.B. OjekaleO. LawalM.O. LasisiC.A. BamgboseF.A. Dosu Recently in Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase. This paper therefore evaluates the bioactive compounds of three herbal drinks and their concomitant effects on selected hepatic biomarkers in albino Wister rats in Lagos, Nigeria using standard methods. A total of 31 bioactive compounds were positively identified in the three bitter drinks analyzed, Out of which are: Yoyo (5-Hydroxymethylfurfural (6.8%), Coumaran (1.7%), Octamethyl cyclotetrasiloxane ( 4.5%), Squalene(3.2%) - 2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one(1.7%),3,3-Dimethyl-2butanol(1.1%),2-Hydroxy-2- cyclopenten-1-one (0.7%)). Swedish (Camphor (82.9%), Cinnamic acid (0.2%)). Living (5-Hydroxymethylfurfural 57.4%), Coumaran (1.6%), 3, 4-dihydroxy-3-cyclobutene-1, 2-dione (0.3%). The three bitters had no common bioactive compound between them. Five common bioactive compounds were detected present in both Living and Yoyo bitters. Only 11 (about 35%) of the 31 compounds identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. The three bitters orally administered to rats from data gathered were not dangerous to the liver over the 40day period of the experiment. Keywords: Yoyo, Swedish, living, hepatic biomarkers https://www.ajol.info/index.php/jasem/article/view/192515YoyoSwedishlivinghepatic biomarkers |
| spellingShingle | A.B. Ojekale O. Lawal M.O. Lasisi C.A. Bamgbose F.A. Dosu Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria Journal of Applied Sciences and Environmental Management Yoyo Swedish living hepatic biomarkers |
| title | Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria |
| title_full | Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria |
| title_fullStr | Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria |
| title_full_unstemmed | Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria |
| title_short | Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria |
| title_sort | bioactive compounds in herbal bitter drinks and effects on selected hepatic biomarkers in albino wister rats in lagos nigeria |
| topic | Yoyo Swedish living hepatic biomarkers |
| url | https://www.ajol.info/index.php/jasem/article/view/192515 |
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