In vitro and in silico characterization of adiponectin-receptor agonist dipeptides

In vitro and in silico characterization of adiponectin-receptor agonist dipeptides

Abstract The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on the structure of the AdipoR1 agonist, AdipoRon, 15 synthetic dipeptides were targeted to promote glucose uptake in L6 myotubes. Tyr-Pro showe...

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Bibliographic Details
Main Authors:	Yuna Lee, Akihiro Nakano, Saya Nakamura, Kenta Sakai, Mitsuru Tanaka, Keisuke Sanematsu, Noriatsu Shigemura, Toshiro Matsui
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-11-01
Series:	npj Science of Food
Online Access:	https://doi.org/10.1038/s41538-021-00114-2

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