mGluR1-Dependent Long Term Depression in Rodent Midbrain Dopamine Neurons Is Regulated by Neuregulin 1/ErbB Signaling

mGluR1-Dependent Long Term Depression in Rodent Midbrain Dopamine Neurons Is Regulated by Neuregulin 1/ErbB Signaling

Increasing evidence demonstrates that the neurotrophic factor Neuregulin 1 (NRG1) and its receptors, ErbB tyrosine kinases, modulate midbrain dopamine (DA) transmission. We have previously reported that NRG1/ErbB signaling is essential for proper metabotropic glutamate receptors 1 (mGluR1) functioni...

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Bibliographic Details
Main Authors: Ada Ledonne, Nicola Biagio Mercuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuregulin 1
ErbB signaling
group 1 metabotropic glutamate receptors (mGluRI)
synaptic plasticity
LTD
dopamine
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00346/full

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