Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses
The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/04177 |
| _version_ | 1829096798098030592 |
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| author | Shiho Chiba Hiroaki Ikushima Hiroshi Ueki Hideyuki Yanai Yoshitaka Kimura Sho Hangai Junko Nishio Hideo Negishi Tomohiko Tamura Shinobu Saijo Yoichiro Iwakura Tadatsugu Taniguchi |
| author_facet | Shiho Chiba Hiroaki Ikushima Hiroshi Ueki Hideyuki Yanai Yoshitaka Kimura Sho Hangai Junko Nishio Hideo Negishi Tomohiko Tamura Shinobu Saijo Yoichiro Iwakura Tadatsugu Taniguchi |
| author_sort | Shiho Chiba |
| collection | DOAJ |
| description | The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications. |
| first_indexed | 2024-04-11T09:03:15Z |
| format | Article |
| id | doaj.art-d6a97e0647dd4d0982b39c8e417e084d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:03:15Z |
| publishDate | 2014-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d6a97e0647dd4d0982b39c8e417e084d2022-12-22T04:32:43ZengeLife Sciences Publications LtdeLife2050-084X2014-08-01310.7554/eLife.04177Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responsesShiho Chiba0Hiroaki Ikushima1Hiroshi Ueki2Hideyuki Yanai3Yoshitaka Kimura4Sho Hangai5Junko Nishio6Hideo Negishi7Tomohiko Tamura8Shinobu Saijo9Yoichiro Iwakura10Tadatsugu Taniguchi11Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Tokyo, Japan; Japan Science and Technology Agency, Core Research for Evolution Science and Technology, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Japan Science and Technology Agency, Core Research for Evolution Science and Technology, Tokyo, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Japan Science and Technology Agency, Core Research for Evolution Science and Technology, Tokyo, JapanDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, JapanCenter for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, JapanDepartment of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Tokyo, Japan; Japan Science and Technology Agency, Core Research for Evolution Science and Technology, Tokyo, JapanThe eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications.https://elifesciences.org/articles/04177innate immunityDectin-1NK cellIRF |
| spellingShingle | Shiho Chiba Hiroaki Ikushima Hiroshi Ueki Hideyuki Yanai Yoshitaka Kimura Sho Hangai Junko Nishio Hideo Negishi Tomohiko Tamura Shinobu Saijo Yoichiro Iwakura Tadatsugu Taniguchi Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses eLife innate immunity Dectin-1 NK cell IRF |
| title | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses |
| title_full | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses |
| title_fullStr | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses |
| title_full_unstemmed | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses |
| title_short | Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses |
| title_sort | recognition of tumor cells by dectin 1 orchestrates innate immune cells for anti tumor responses |
| topic | innate immunity Dectin-1 NK cell IRF |
| url | https://elifesciences.org/articles/04177 |
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