Myogenin promotes myocyte fusion to balance fibre number and size
Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast musc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06583-6 |
| _version_ | 1828903383374757888 |
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| author | Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes |
| author_facet | Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes |
| author_sort | Massimo Ganassi |
| collection | DOAJ |
| description | Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number. |
| first_indexed | 2024-12-13T16:34:10Z |
| format | Article |
| id | doaj.art-d6aaafc55e244efe901b9d6408377f25 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:34:10Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d6aaafc55e244efe901b9d6408377f252022-12-21T23:38:27ZengNature PortfolioNature Communications2041-17232018-10-019111710.1038/s41467-018-06583-6Myogenin promotes myocyte fusion to balance fibre number and sizeMassimo Ganassi0Sara Badodi1Huascar Pedro Ortuste Quiroga2Peter S. Zammit3Yaniv Hinits4Simon M. Hughes5Randall Centre for Cell and Molecular Biophysics, King’s College LondonBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonRandall Centre for Cell and Molecular Biophysics, King’s College LondonRandall Centre for Cell and Molecular Biophysics, King’s College LondonRandall Centre for Cell and Molecular Biophysics, King’s College LondonRandall Centre for Cell and Molecular Biophysics, King’s College LondonLoss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number.https://doi.org/10.1038/s41467-018-06583-6 |
| spellingShingle | Massimo Ganassi Sara Badodi Huascar Pedro Ortuste Quiroga Peter S. Zammit Yaniv Hinits Simon M. Hughes Myogenin promotes myocyte fusion to balance fibre number and size Nature Communications |
| title | Myogenin promotes myocyte fusion to balance fibre number and size |
| title_full | Myogenin promotes myocyte fusion to balance fibre number and size |
| title_fullStr | Myogenin promotes myocyte fusion to balance fibre number and size |
| title_full_unstemmed | Myogenin promotes myocyte fusion to balance fibre number and size |
| title_short | Myogenin promotes myocyte fusion to balance fibre number and size |
| title_sort | myogenin promotes myocyte fusion to balance fibre number and size |
| url | https://doi.org/10.1038/s41467-018-06583-6 |
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