Quality of melatonin use in children and adolescents: findings from a UK clinical audit
Background Melatonin is commonly used to treat sleep disturbance in children and adolescents, although uncertainties about its optimal use remain.Objective To determine to what extent prescribing of melatonin complies with evidence-based clinical practice standards.Methods As part of a quality impro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-01-01
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| Series: | BMJ Mental Health |
| Online Access: | https://ebmh.bmj.com/content/27/1/e300894.full |
| _version_ | 1797349121099563008 |
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| author | Paul Gringras Thomas R E Barnes Carol Paton Ashley Liew Alice Ruan Olivia Rendora Gaia Bove |
| author_facet | Paul Gringras Thomas R E Barnes Carol Paton Ashley Liew Alice Ruan Olivia Rendora Gaia Bove |
| author_sort | Paul Gringras |
| collection | DOAJ |
| description | Background Melatonin is commonly used to treat sleep disturbance in children and adolescents, although uncertainties about its optimal use remain.Objective To determine to what extent prescribing of melatonin complies with evidence-based clinical practice standards.Methods As part of a quality improvement programme, the Prescribing Observatory for Mental Health conducted a retrospective clinical audit in UK services for children and adolescents.Findings Data were submitted for 4151 children and adolescents up to 18 years of age, treated with melatonin: 3053 (74%) had a diagnosis of neurodevelopmental disorder. In 2655 (73%) of the 3651 patients prescribed melatonin to be taken regularly, the main reason was to reduce sleep latency (time taken to fall asleep). In 409 patients recently starting melatonin, a non-pharmacological intervention had already been tried in 279 (68%). The therapeutic response of patients early in treatment (n=899) and on long-term treatment (n=2353) had been assessed and quantified in 36% and 31%, respectively, while for review of side effects, the respective proportions were 46% and 43%. Planned treatment breaks were documented in 317 (13%) of those on long-term treatment.Conclusions Melatonin was predominantly prescribed for evidence-based clinical indications, but the clinical review and monitoring of this treatment fell short of best practice.Clinical implications With limited methodical review of melatonin use in their patients, clinicians will fail to garner reliable information on its risks and benefits for individual patients. The lack of such practice-based evidence may increase the risk of melatonin being inappropriately targeted or continued despite being ineffective or no longer indicated. |
| first_indexed | 2024-03-08T12:24:38Z |
| format | Article |
| id | doaj.art-d6ab031a7c10478bbbe829736c91c158 |
| institution | Directory Open Access Journal |
| issn | 2755-9734 |
| language | English |
| last_indexed | 2024-03-08T12:24:38Z |
| publishDate | 2024-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Mental Health |
| spelling | doaj.art-d6ab031a7c10478bbbe829736c91c1582024-01-22T10:50:08ZengBMJ Publishing GroupBMJ Mental Health2755-97342024-01-0127110.1136/bmjment-2023-300894Quality of melatonin use in children and adolescents: findings from a UK clinical auditPaul Gringras0Thomas R E Barnes1Carol Paton2Ashley Liew3Alice Ruan4Olivia Rendora5Gaia Bove6Women’s and Children’s Institute, King`s College London, London, UKprofessor1 Prescribing Observatory for Mental Health (POMH-UK), Royal College of Psychiatrists, London, UK3 Evelina London Children`s Hospital, King`s College London, London, UK4 Department of Endocrinology, Imperial College London, London, UK1 Prescribing Observatory for Mental Health, Royal College of Psychiatrists, London, UK1 Prescribing Observatory for Mental Health, Royal College of Psychiatrists, London, UKBackground Melatonin is commonly used to treat sleep disturbance in children and adolescents, although uncertainties about its optimal use remain.Objective To determine to what extent prescribing of melatonin complies with evidence-based clinical practice standards.Methods As part of a quality improvement programme, the Prescribing Observatory for Mental Health conducted a retrospective clinical audit in UK services for children and adolescents.Findings Data were submitted for 4151 children and adolescents up to 18 years of age, treated with melatonin: 3053 (74%) had a diagnosis of neurodevelopmental disorder. In 2655 (73%) of the 3651 patients prescribed melatonin to be taken regularly, the main reason was to reduce sleep latency (time taken to fall asleep). In 409 patients recently starting melatonin, a non-pharmacological intervention had already been tried in 279 (68%). The therapeutic response of patients early in treatment (n=899) and on long-term treatment (n=2353) had been assessed and quantified in 36% and 31%, respectively, while for review of side effects, the respective proportions were 46% and 43%. Planned treatment breaks were documented in 317 (13%) of those on long-term treatment.Conclusions Melatonin was predominantly prescribed for evidence-based clinical indications, but the clinical review and monitoring of this treatment fell short of best practice.Clinical implications With limited methodical review of melatonin use in their patients, clinicians will fail to garner reliable information on its risks and benefits for individual patients. The lack of such practice-based evidence may increase the risk of melatonin being inappropriately targeted or continued despite being ineffective or no longer indicated.https://ebmh.bmj.com/content/27/1/e300894.full |
| spellingShingle | Paul Gringras Thomas R E Barnes Carol Paton Ashley Liew Alice Ruan Olivia Rendora Gaia Bove Quality of melatonin use in children and adolescents: findings from a UK clinical audit BMJ Mental Health |
| title | Quality of melatonin use in children and adolescents: findings from a UK clinical audit |
| title_full | Quality of melatonin use in children and adolescents: findings from a UK clinical audit |
| title_fullStr | Quality of melatonin use in children and adolescents: findings from a UK clinical audit |
| title_full_unstemmed | Quality of melatonin use in children and adolescents: findings from a UK clinical audit |
| title_short | Quality of melatonin use in children and adolescents: findings from a UK clinical audit |
| title_sort | quality of melatonin use in children and adolescents findings from a uk clinical audit |
| url | https://ebmh.bmj.com/content/27/1/e300894.full |
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